Xirp1 xin actin-binding repeat containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Xirp1provided by RGD
Official Full Name: xin actin-binding repeat containing 1provided by RGD
Primary source: RGD:1304776
See related: EnsemblRapid:ENSRNOG00000037085 AllianceGenome:RGD:1304776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cmya1
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and negative regulation of protein binding activity. Predicted to act upstream of or within several processes, including Notch signaling pathway; muscle cell development; and negative regulation of cell population proliferation. Predicted to be located in adherens junction and fascia adherens. Predicted to colocalize with focal adhesion and stress fiber. Orthologous to human XIRP1 (xin actin binding repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 387.1), Heart (RPKM 380.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (128625111..128635011, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (119744778..119757547, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128694809..128712092, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
Title: An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sarcomere organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in fascia adherens	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: xin actin-binding repeat containing 1; xin actin-binding repeat-containing protein 1

Names: cardiomyopathy associated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430574.1 → NP_001417503.1 xin actin-binding repeat containing 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5YBK9, A6I3Y7
NM_001430575.1 → NP_001417504.1 xin actin-binding repeat containing 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5YBK9, A6I3Y7
NM_001430576.1 → NP_001417505.1 xin actin-binding repeat containing 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5YBK9, A6I3Y7
NM_001430577.1 → NP_001417506.1 xin actin-binding repeat containing 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D4ABA9
NM_001430578.1 → NP_001417507.1 xin actin-binding repeat containing 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D4ABA9
NM_001430579.1 → NP_001417508.1 xin actin-binding repeat containing 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

D4ABA9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

128625111..128635011 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244155.5 → XP_006244217.1 xin actin-binding repeat-containing protein 1 isoform X2

Related

ENSRNOP00000052739.4, ENSRNOT00000055888.5

Conserved Domains (1) summary

pfam08043
Location:549 → 562

Xin; Xin repeat
XM_006244151.5 → XP_006244213.1 xin actin-binding repeat-containing protein 1 isoform X1

Related

ENSRNOP00000091019.1, ENSRNOT00000101246.2

Conserved Domains (2) summary

PHA03247
Location:902 → 1293

PHA03247; large tegument protein UL36; Provisional

pfam08043
Location:510 → 525

Xin; Xin repeat
XM_008766701.4 → XP_008764923.1 xin actin-binding repeat-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_008764923.1

UniProtKB/TrEMBL

A0A8I5YBK9, A6I3Y7

Conserved Domains (2) summary

PHA03247
Location:902 → 1293

PHA03247; large tegument protein UL36; Provisional

pfam08043
Location:510 → 525

Xin; Xin repeat
XM_063266351.1 → XP_063122421.1 xin actin-binding repeat-containing protein 1 isoform X2
XM_017596154.3 → XP_017451643.1 xin actin-binding repeat-containing protein 1 isoform X1

Related

ENSRNOP00000077004.1, ENSRNOT00000093872.2

Conserved Domains (2) summary

PHA03247
Location:902 → 1293

PHA03247; large tegument protein UL36; Provisional

pfam08043
Location:510 → 525

Xin; Xin repeat
XM_063266352.1 → XP_063122422.1 xin actin-binding repeat-containing protein 1 isoform X2
XM_039082728.2 → XP_038938656.1 xin actin-binding repeat-containing protein 1 isoform X1

Conserved Domains (2) summary

PHA03247
Location:902 → 1293

PHA03247; large tegument protein UL36; Provisional

pfam08043
Location:510 → 525

Xin; Xin repeat