SCART1 scavenger receptor family member expressed on T cells 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCART1provided by HGNC
Official Full Name: scavenger receptor family member expressed on T cells 1provided by HGNC
Primary source: HGNC:HGNC:32411
See related: Ensembl:ENSG00000214279 AllianceGenome:HGNC:32411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to be involved in immune system process. Located in brush border and cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen (RPKM 1.2), endometrium (RPKM 0.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (133453945..133469760)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (134408221..134424034)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (135267449..135283264)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the characterization of hSCART1 at the mRNA and protein level suggests that the protein plays a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T cells.
Title: Characterization of a novel human scavenger receptor cysteine-rich molecule SCART1 expressed by lymphocytes.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

SHGC-155358 (e-PCR)
- UniSTS:182295

SHGC-156078 (e-PCR)
- UniSTS:182320

D10S2490 (e-PCR)
- UniSTS:36844

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in T cell mediated immunity	NAS Non-traceable Author Statement more info	PubMed
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: scavenger receptor cysteine-rich domain-containing protein SCART1

Names: CD163c-alpha; scavenger receptor protein family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396050.1 → NP_001382979.1 scavenger receptor cysteine-rich domain-containing protein SCART1 precursor

Status: VALIDATED

Source sequence(s)

AL161645

Consensus CDS

CCDS91391.1

UniProtKB/Swiss-Prot

C9K0L3, Q4G0T1

Related

ENSP00000491516.1, ENST00000640237.2

Conserved Domains (2) summary

smart00202
Location:786 → 885

SR; Scavenger receptor Cys-rich

pfam00530
Location:439 → 534

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

133453945..133469760

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

134408221..134424034

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001033584.1: Suppressed sequence

Description

NM_001033584.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
NR_002934.3: Suppressed sequence

Description

NR_002934.3: This RefSeq was removed because currently there is insufficient support for the transcript structure.
NR_149718.1: Suppressed sequence

Description

NR_149718.1: This RefSeq was removed because it is now thought that this gene does encode a protein.