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    NTPCR nucleoside-triphosphatase, cancer-related [ Homo sapiens (human) ]

    Gene ID: 84284, updated on 14-Nov-2024

    Summary

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    Official Symbol
    NTPCRprovided by HGNC
    Official Full Name
    nucleoside-triphosphatase, cancer-relatedprovided by HGNC
    Primary source
    HGNC:HGNC:28204
    See related
    Ensembl:ENSG00000135778 AllianceGenome:HGNC:28204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THEP1; C1orf57; HCR-NTPase
    Summary
    The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in brain (RPKM 18.5), kidney (RPKM 18.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NTPCR in Genome Data Viewer
    Location:
    1q42.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (232950611..232983882)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (232336950..232370221)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (233086357..233119628)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927711 Neighboring gene RNA, U1 small nuclear 74, pseudogene Neighboring gene uncharacterized LOC105373201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2733 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:233059320-233060519 Neighboring gene uncharacterized LOC107985361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233086091-233086632 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233086633-233087172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233088301-233088800 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:233113500-233114699 Neighboring gene pecanex 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:233215157-233215658 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:233215659-233216158 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:233250348-233251547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:233264306-233264818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:233264819-233265329 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:233314891-233316090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233370205-233370728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233370729-233371250 Neighboring gene Sharpr-MPRA regulatory region 15021 Neighboring gene MPRA-validated peak771 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:233393606-233394805 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233422285-233422784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:233421783-233422284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1960 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:233463573-233463724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1962 Neighboring gene ribosomal protein S7 pseudogene 3 Neighboring gene mitogen-activated protein kinase kinase kinase 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:233507364-233507864

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y. Pasdziernik M, et al. BMC Res Notes, 2009 Jun 11. PMID 19519914, Free PMC Article
    2. Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1. Sabbir MG. J Steroid Biochem Mol Biol, 2019 Jul. PMID 31067491
    3. NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase. Placzek WJ, et al. J Mol Biol, 2007 Mar 30. PMID 17291528
    4. Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells. Yang Z, et al. Vaccines (Basel), 2022 Nov 29. PMID 36560452, Free PMC Article
    5. Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Miotto B, et al. Nucleic Acids Res, 2018 May 18. PMID 29490077, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11383, MGC13186

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    cancer-related nucleoside-triphosphatase
    Names
    human cancer-related NTPase
    nucleoside triphosphate phosphohydrolase
    nucleoside-triphosphatase C1orf57
    NP_001316381.1
    NP_001316382.1
    NP_115700.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329452.2 → NP_001316381.1  cancer-related nucleoside-triphosphatase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL122003, BQ001389

    2. NM_001329453.2 → NP_001316382.1  cancer-related nucleoside-triphosphatase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AA635564, AL122003, BC005102, BQ001389, HY133356
      UniProtKB/Swiss-Prot
      Q9BSD7
      Conserved Domains (1) summary
      cl21455
      Location:4 → 102
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_032324.3 → NP_115700.1  cancer-related nucleoside-triphosphatase isoform 1

      See identical proteins and their annotated locations for NP_115700.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL122003, BC005102, BQ001389, HY133356
      Consensus CDS
      CCDS1597.1
      UniProtKB/Swiss-Prot
      Q9BSD7
      UniProtKB/TrEMBL
      Q5TDE9
      Related
      ENSP00000355587.4, ENST00000366628.10
      Conserved Domains (1) summary
      pfam03266
      Location:4 → 182
      NTPase_1; NTPase

    RNA

    1. NR_138024.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL122003, BC005102, BG106026, BQ001389, HY133356

    2. NR_138025.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL122003, BC005102, BF663221, BQ001389, HY133356

    3. NR_138026.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL122003, BC005102, BQ001389, HY133356, W80669

    4. NR_138027.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL122003, BC005102, BG473925, BQ001389

    5. NR_138028.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL122003, BC005102, BQ001389, DC332692, HY133356

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      232950611..232983882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      232336950..232370221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BSD7.1 GenPept UniProtKB/Swiss-Prot:Q9BSD7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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