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    PRSS37 serine protease 37 [ Homo sapiens (human) ]

    Gene ID: 136242, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PRSS37provided by HGNC
    Official Full Name
    serine protease 37provided by HGNC
    Primary source
    HGNC:HGNC:29211
    See related
    Ensembl:ENSG00000165076 AllianceGenome:HGNC:29211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRYX2
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of acrosome reaction and regulation of protein processing. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis (RPKM 1.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See PRSS37 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (141836278..141841485, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (143152100..143157307, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141536078..141541285, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MT-ND1 pseudogene 3 Neighboring gene MYL6 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:141537551-141537755 Neighboring gene olfactory receptor family 9 subfamily A member 3 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr7:141575140-141575702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:141576176-141576676 Neighboring gene olfactory receptor family 9 subfamily A member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility. Liu J, et al. Acta Biochim Biophys Sin (Shanghai), 2016 Nov. PMID 27649891
    2. Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Freitas MJ, et al. Mol Hum Reprod, 2019 Apr 1. PMID 30824926, Free PMC Article
    3. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in germ cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    probable inactive serine protease 37
    Names
    Peptidase S1 domain-containing protein LOC136242
    probable inactive trypsin-X2
    protease, serine 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008270.3 → NP_001008271.2  probable inactive serine protease 37 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001008271.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA628371, AC093638, AK172866, BC137353
      Consensus CDS
      CCDS34764.1
      UniProtKB/Swiss-Prot
      A4D1T9, B2RPB5
      Related
      ENSP00000297767.3, ENST00000350549.8
      Conserved Domains (1) summary
      cl21584
      Location:28 → 231
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001171951.2 → NP_001165422.1  probable inactive serine protease 37 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001165422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA628371, AC093638, AK172866, BC144605
      UniProtKB/TrEMBL
      B7ZMK3
      Conserved Domains (2) summary
      smart00020
      Location:28 → 227
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:28 → 230
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_001370403.1 → NP_001357332.1  probable inactive serine protease 37 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC093638
      Consensus CDS
      CCDS34764.1
      UniProtKB/Swiss-Prot
      A4D1T9, B2RPB5
      Related
      ENSP00000414461.1, ENST00000438520.1
      Conserved Domains (1) summary
      cl21584
      Location:28 → 231
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      141836278..141841485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249947.4 → XP_005250004.1  probable inactive serine protease 37 isoform X1

      See identical proteins and their annotated locations for XP_005250004.1

      Conserved Domains (2) summary
      smart00020
      Location:28 → 258
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:28 → 261
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_047419883.1 → XP_047275839.1  probable inactive serine protease 37 isoform X2

    3. XM_047419884.1 → XP_047275840.1  probable inactive serine protease 37 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      143152100..143157307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357235.1 → XP_054213210.1  probable inactive serine protease 37 isoform X1

    2. XM_054357236.1 → XP_054213211.1  probable inactive serine protease 37 isoform X2

    3. XM_054357237.1 → XP_054213212.1  probable inactive serine protease 37 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4D1T9.1 GenPept UniProtKB/Swiss-Prot:A4D1T9

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