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    BOL3 Bol3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851251, updated on 28-Oct-2024

    Summary

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    Official Symbol
    BOL3
    Official Full Name
    Bol3p
    Primary source
    SGD:S000000044
    Locus tag
    YAL046C
    See related
    AllianceGenome:SGD:S000000044; FungiDB:YAL046C; VEuPathDB:YAL046C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM1
    Summary
    Involved in protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Orthologous to human BOLA3 (bolA family member 3). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See BOL3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (57029..57385, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene ERMES complex Ca(2+)-binding regulatory GTPase GEM1 Neighboring gene gamma-tubulin complex subunit SPC72 Neighboring gene Bol1p Neighboring gene glycine decarboxylase subunit H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins. Uzarska MA, et al. Elife, 2016 Aug 17. PMID 27532772, Free PMC Article
    2. Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients. Melber A, et al. Elife, 2016 Aug 17. PMID 27532773, Free PMC Article
    3. A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae. Lam MH, et al. J Mol Biol, 2015 Jun 5. PMID 25644660, Free PMC Article
    4. Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium. Scherz K, et al. G3 (Bethesda), 2014 Jul 9. PMID 25009170, Free PMC Article
    5. The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Bussey H, et al. Proc Natl Acad Sci U S A, 1995 Apr 25. PMID 7731988, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein maturation by [4Fe-4S] cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by [4Fe-4S] cluster transfer IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bol3p
    NP_009353.1
    • Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      57029..57385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178191.1 → NP_009353.1  TPA: Bol3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPH0, P39724
      UniProtKB/TrEMBL
      A7A0C0, B3LUY2, C7GPJ1, C8Z3G6, G2W8I4, N1P7G9
      Conserved Domains (1) summary
      COG0271
      Location:33 → 110
      BolA; Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39724.1

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