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    POP8 ribonuclease P [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852263, updated on 28-Oct-2024

    Summary

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    Official Symbol
    POP8
    Official Full Name
    ribonuclease P
    Primary source
    SGD:S000000114
    Locus tag
    YBL018C
    See related
    AllianceGenome:SGD:S000000114; FungiDB:YBL018C; VEuPathDB:YBL018C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in intronic box C/D snoRNA processing; nuclear-transcribed mRNA catabolic process, RNase MRP-dependent; and tRNA processing. Located in cytosol and nucleus. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See POP8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (185998..186474, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene glycolipid translocation protein Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN2 Neighboring gene type I sorting receptor Neighboring gene mitogen-activated serine/threonine-protein kinase FUS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components. Lu Q, et al. RNA, 2010 Mar. PMID 20086051, Free PMC Article
    2. In vitro reconstitution and analysis of eukaryotic RNase P RNPs. Perederina A, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29722866, Free PMC Article
    3. Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Stohl LL, et al. Mol Cell Biol, 1992 Jun. PMID 1588958, Free PMC Article
    4. Yeast RNase P: catalytic activity and substrate binding are separate functions. Nichols M, et al. Proc Natl Acad Sci U S A, 1988 Mar. PMID 3278310, Free PMC Article
    5. Evidence for an RNA-based catalytic mechanism in eukaryotic nuclear ribonuclease P. Thomas BC, et al. RNA, 2000 Apr. PMID 10786846, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease MRP activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease MRP activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intronic box C/D snoRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intronic box C/D snoRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease P
    NP_009535.1
    • Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      185998..186474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178258.1 → NP_009535.1  TPA: ribonuclease P [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009535.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPY2, P38208
      UniProtKB/TrEMBL
      A6ZKT0, C8Z3X8, G2W8Z1, N1P907
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38208.1

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