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    SHE1 She1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852249, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SHE1
    Gene description
    She1p
    Primary source
    FungiDB:YBL031W
    Locus tag
    YBL031W
    See related
    SGD:S000000127; AllianceGenome:SGD:S000000127; VEuPathDB:YBL031W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables microtubule binding activity. Involved in mitotic spindle elongation. Located in cellular bud neck; nuclear microtubule; and spindle. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SHE1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (161699..162715)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase II Neighboring gene Hek2p Neighboring gene ADP/ATP carrier protein PET9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microtubule-associated protein She1 coordinates directional spindle positioning by spatially restricting dynein activity. Ecklund KH, et al. J Cell Sci, 2021 Dec 1. PMID 34854468, Free PMC Article
    2. Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function. Denarier E, et al. Mol Biol Cell, 2021 Oct 1. PMID 34379441, Free PMC Article
    3. She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain. Ecklund KH, et al. Nat Commun, 2017 Dec 15. PMID 29247176, Free PMC Article
    4. Microtubule cross-linking activity of She1 ensures spindle stability for spindle positioning. Zhu Y, et al. J Cell Biol, 2017 Sep 4. PMID 28794129, Free PMC Article
    5. She1-mediated inhibition of dynein motility along astral microtubules promotes polarized spindle movements. Markus SM, et al. Curr Biol, 2012 Dec 4. PMID 23142046, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. collides with and pauses motile dynein motors, prolonging their attachment to the microtubule
      Title: She1-mediated inhibition of dynein motility along astral microtubules promotes polarized spindle movements.
    2. Data suggest that She1p restricts dynein-dependent spindle positioning to anaphase by inhibiting the association of dynein with the complete dynactin complex.
      Title: Dynein-driven mitotic spindle positioning restricted to anaphase by She1p inhibition of dynactin recruitment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton HDA PubMed 
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    She1p
    NP_009522.1
    • Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      161699..162715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178271.1 → NP_009522.1  TPA: She1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZKR6, D6VPW8, P38200
      UniProtKB/TrEMBL
      A0A8H4BV48, N1P7E1
      Conserved Domains (1) summary
      pfam17077
      Location:34 → 328
      Msap1; Mitotic spindle associated protein SHE1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38200.1

    Gene LinkOut

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