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    APL3 Apl3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852243, updated on 28-Oct-2024

    Summary

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    Official Symbol
    APL3
    Official Full Name
    Apl3p
    Primary source
    SGD:S000000133
    Locus tag
    YBL037W
    See related
    AllianceGenome:SGD:S000000133; FungiDB:YBL037W; VEuPathDB:YBL037W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in clathrin-dependent endocytosis. Located in cellular bud neck. Part of AP-2 adaptor complex. Orthologous to several human genes including AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See APL3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (147209..150286)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene CTP synthase URA7 Neighboring gene mitochondrial 54S ribosomal protein YmL47 Neighboring gene uncharacterized protein Neighboring gene DNA-directed DNA polymerase alpha subunit POL12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Light-dependent inhibition of clathrin-mediated endocytosis in yeast unveils conserved functions of the AP2 complex. Prischich D, et al. iScience, 2023 Oct 20. PMID 37766990, Free PMC Article
    2. Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses. Chapa-y-Lazo B, et al. Traffic, 2014 May. PMID 24460703, Free PMC Article
    3. Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. Panek HR, et al. EMBO J, 1997 Jul 16. PMID 9250663, Free PMC Article
    4. Adaptor complex-independent clathrin function in yeast. Yeung BG, et al. Mol Biol Cell, 1999 Nov. PMID 10564262, Free PMC Article
    5. Alpha-arrestins Aly1/Art6 and Aly2/Art3 regulate trafficking of the glycerophosphoinositol transporter Git1 and impact phospholipid homeostasis. Robinson BP, et al. Biol Cell, 2022 Jan. PMID 34562280

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-2 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-2 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apl3p
    NP_009516.1
    • Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      147209..150286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178277.1 → NP_009516.1  TPA: Apl3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009516.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPW2, P38065
      UniProtKB/TrEMBL
      A6ZKR0, N1P8S3
      Conserved Domains (2) summary
      pfam02296
      Location:901 → 1018
      Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
      pfam01602
      Location:38 → 649
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38065.1

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