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    URA7 CTP synthase URA7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852241, updated on 18-Sep-2024

    Summary

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    Official Symbol
    URA7
    Official Full Name
    CTP synthase URA7
    Primary source
    SGD:S000000135
    Locus tag
    YBL039C
    See related
    AllianceGenome:SGD:S000000135; FungiDB:YBL039C; VEuPathDB:YBL039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables CTP synthase activity. Involved in CTP biosynthetic process; phospholipid biosynthetic process; and pyrimidine nucleobase biosynthetic process. Located in cytoophidium. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See URA7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (143989..145728, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Erd2p Neighboring gene Min6p Neighboring gene mitochondrial 54S ribosomal protein YmL47 Neighboring gene Apl3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypoosmolality impedes cytoophidium integrity during nitrogen starvation. Li YL, et al. Yeast, 2021 Apr. PMID 33294993
    2. Common regulatory control of CTP synthase enzyme activity and filament formation. Noree C, et al. Mol Biol Cell, 2014 Aug 1. PMID 24920825, Free PMC Article
    3. Characterization of a novel dUTP-dependent activity of CTP synthetase from Saccharomyces cerevisiae. Pappas A, et al. Biochemistry, 1999 Dec 14. PMID 10600130
    4. Identification of Ser424 as the protein kinase A phosphorylation site in CTP synthetase from Saccharomyces cerevisiae. Park TS, et al. Biochemistry, 1999 Jul 6. PMID 10393561
    5. Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae. Pappas A, et al. J Biol Chem, 1998 Jun 26. PMID 9632643

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Performed a genome-wide screen in Saccharomyces cerevisiae to identify genes linked to high-fidelity DNA replication. Found URA7 or GLN3 inactivation had a role in imbalanced dNTP pools and increased mutagenesis.
      Title: Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.
    2. The regulatory sites that control CTP synthase function, but not enzymatic activity per se, are critical for controlling filament assembly.
      Title: Common regulatory control of CTP synthase enzyme activity and filament formation.
    3. URA7 has a role in ethanol tolerance.
      Title: Disruption of URA7 and GAL6 improves the ethanol tolerance and fermentation capacity of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CTP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CTP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CTP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleobase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoophidium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoophidium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    CTP synthase URA7
    NP_009514.1
    • Major CTP synthase isozyme (see also URA8); catalyzes ATP-dependent transfer of amide nitrogen from glutamine to UTP, forming CTP, final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; targeted to vacuole via AP-3 pathway; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has paralog URA8 that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      143989..145728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178279.1 → NP_009514.1  TPA: CTP synthase URA7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009514.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPW0, P28274
      UniProtKB/TrEMBL
      A6ZKQ8, B3LNH7, C7GNC4, C8Z3Q9, G2W8W9, N1P8Z5
      Conserved Domains (1) summary
      TIGR00337
      Location:1 → 555
      PyrG; CTP synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28274.2

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