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    CSH1 mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852458, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CSH1
    Official Full Name
    mannosylinositol phosphorylceramide synthase catalytic subunit CSH1
    Primary source
    SGD:S000000365
    Locus tag
    YBR161W
    See related
    AllianceGenome:SGD:S000000365; FungiDB:YBR161W; VEuPathDB:YBR161W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables inositol phosphorylceramide mannosyltransferase activity. Involved in glycosphingolipid biosynthetic process. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CSH1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (561634..562764)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ketoreductase Neighboring gene cyclin-dependent serine/threonine-protein kinase CDC28 Neighboring gene Tos1p Neighboring gene Ysy6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae. Uemura S, et al. Glycobiology, 2022 Aug 18. PMID 35713525
    2. Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces cerevisiae reveals two new open reading frames next to CDC28. Baur S, et al. Yeast, 1995 Apr 30. PMID 7597849
    3. Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p. Uemura S, et al. J Biol Chem, 2003 Nov 14. PMID 12954640
    4. HOR7, a multicopy suppressor of the Ca2+-induced growth defect in sphingolipid mannosyltransferase-deficient yeast. Lisman Q, et al. J Biol Chem, 2004 Aug 27. PMID 15208314
    5. Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2. Uemura S, et al. J Biol Chem, 2007 Mar 23. PMID 17220303

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
      Title: Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
    2. Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
      Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables inositol phosphorylceramide mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol phosphorylceramide mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycosphingolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inositol phosphoceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannosyl-inositol phosphorylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannosylinositol phosphorylceramide synthase catalytic subunit CSH1
    NP_009719.3
    • Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      561634..562764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178509.3 → NP_009719.3  TPA: mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009719.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQF6, P38287
      UniProtKB/TrEMBL
      A6ZLA3, B3LMZ8, B5VEB7, C7GUH5, D3UEQ5, G2W9G3, N1PAU1
      Conserved Domains (1) summary
      COG3774
      Location:1 → 332
      OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38287.1

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