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    BIT2 Bit2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852573, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BIT2
    Official Full Name
    Bit2p
    Primary source
    SGD:S000000474
    Locus tag
    YBR270C
    See related
    AllianceGenome:SGD:S000000474; FungiDB:YBR270C; VEuPathDB:YBR270C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in TORC2 signaling. Part of TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BIT2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (742761..744398, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL37 Neighboring gene Sdh8p Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Hsm3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOR2 is required for organization of the actin cytoskeleton in yeast. Schmidt A, et al. Proc Natl Acad Sci U S A, 1996 Nov 26. PMID 8943012, Free PMC Article
    2. Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Gaubitz C, et al. Mol Cell, 2015 Jun 18. PMID 26028537
    3. The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Fadri M, et al. Mol Biol Cell, 2005 Apr. PMID 15689497, Free PMC Article
    4. Direct in vivo access to potential gene targets of the RPD3 histone deactylase using fitness-based interferential genetics. Daniel J. Yeast, 2007 Jul. PMID 17533620
    5. Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome. Cagney G, et al. Physiol Genomics, 2001 Oct 10. PMID 11595789

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bit2p
    NP_009829.2
    • Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      742761..744398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178618.2 → NP_009829.2  TPA: Bit2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009829.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQR6, P38346
      UniProtKB/TrEMBL
      B3LMP2, N1PAW4
      Conserved Domains (1) summary
      pfam08539
      Location:326 → 482
      HbrB; HbrB-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38346.2

    Gene LinkOut

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