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    NHP10 Nhp10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851562, updated on 28-Oct-2024

    Summary

    Official Symbol
    NHP10
    Official Full Name
    Nhp10p
    Primary source
    SGD:S000002160
    Locus tag
    YDL002C
    See related
    AllianceGenome:SGD:S000002160; FungiDB:YDL002C; VEuPathDB:YDL002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HMO2
    Summary
    Enables DNA end binding activity and heteroduplex DNA loop binding activity. Involved in chromatin remodeling; double-strand break repair; and telomere maintenance via recombination. Located in nucleus. Part of Ino80 complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

    See NHP10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (446967..447578, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit delta Neighboring gene kleisin alpha Neighboring gene Rmd1p Neighboring gene alpha,alpha-trehalase NTH1

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heteroduplex DNA loop binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance via recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Nhp10p
    NP_010282.3
    • Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      446967..447578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180061.3NP_010282.3  TPA: Nhp10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010282.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRY6, Q03435
      UniProtKB/TrEMBL
      A6ZXW4, B3LGR0, B5VFQ9, C7GXZ2, C8Z4R8, G2WCF2, N1PAB3
      Conserved Domains (1) summary
      COG5648
      Location:24203
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]