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    IWR1 Iwr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851442, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IWR1
    Official Full Name
    Iwr1p
    Primary source
    SGD:S000002273
    Locus tag
    YDL115C
    See related
    AllianceGenome:SGD:S000002273; FungiDB:YDL115C; VEuPathDB:YDL115C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein import into nucleus. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See IWR1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (253995..255126, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cyk3p Neighboring gene Nup84p Neighboring gene short-chain dehydrogenase/reductase Neighboring gene Atg20p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae. Esberg A, et al. PLoS One, 2011. PMID 21695216, Free PMC Article
    2. Iwr1 facilitates RNA polymerase II dynamics during transcription elongation. Gómez-Navarro N, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Jul. PMID 28258010
    3. A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin. Pagé N, et al. Genetics, 2003 Mar. PMID 12663529, Free PMC Article
    4. Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Minaker SW, et al. Genetics, 2013 Mar. PMID 23267056, Free PMC Article
    5. Global analysis of mRNA decay intermediates in Saccharomyces cerevisiae. Harigaya Y, et al. Proc Natl Acad Sci U S A, 2012 Jul 17. PMID 22752303, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iwr1 directs RNA polymerase II nuclear import.
      Title: Iwr1 directs RNA polymerase II nuclear import.
    2. Iwr1p acts early in the formation of the pre-initiation complex by mediating the interaction of certain activators with the basal transcription apparatus
      Title: The yeast RNA polymerase II-associated factor Iwr1p is involved in the basal and regulated transcription of specific genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Iwr1p
    NP_010168.4
    • RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      253995..255126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180174.1 → NP_010168.4  TPA: Iwr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010168.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBP4, D6VRN5, Q07532
      UniProtKB/TrEMBL
      C8Z6I8, N1P5W0
      Conserved Domains (1) summary
      pfam08574
      Location:152 → 220
      Iwr1; Transcription factor Iwr1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07532.2

    Gene LinkOut

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