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    MINK1 misshapen like kinase 1 [ Homo sapiens (human) ]

    Gene ID: 50488, updated on 28-Oct-2024

    Summary

    Official Symbol
    MINK1provided by HGNC
    Official Full Name
    misshapen like kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:17565
    See related
    Ensembl:ENSG00000141503 MIM:609426; AllianceGenome:HGNC:17565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B55; ZC3; MINK; YSK2; MAP4K6; MEKKK 6
    Summary
    This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in skin (RPKM 48.7), brain (RPKM 31.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MINK1 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4833340..4898061)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4722898..4788313)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4736635..4801356)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8045 Neighboring gene chromosome 17 open reading frame 114 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4711183-4712382 Neighboring gene phospholipase D2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4735692-4736478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4752245-4752960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4752961-4753674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:4757141-4758092 Neighboring gene Sharpr-MPRA regulatory region 481 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11550 Neighboring gene RNA, 7SL, cytoplasmic 784, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4805105-4805746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4805747-4806388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11552 Neighboring gene Sharpr-MPRA regulatory region 10924 Neighboring gene chromosome 17 open reading frame 107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4811144-4811970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4811971-4812796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4812797-4813623 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11554 Neighboring gene glycoprotein Ib platelet subunit alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC21111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of AMPA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    misshapen-like kinase 1
    Names
    GCK family kinase MINK
    MAPK/ERK kinase kinase kinase 6
    MEK kinase kinase 6
    misshapen/NIK-related kinase
    mitogen-activated protein kinase kinase kinase kinase 6
    NP_001020108.1
    NP_001308165.1
    NP_056531.1
    NP_722549.2
    NP_733763.1
    XP_006721594.1
    XP_006721595.1
    XP_006721599.1
    XP_011522208.1
    XP_016880193.1
    XP_016880194.1
    XP_016880195.1
    XP_016880196.1
    XP_016880197.1
    XP_047292121.1
    XP_047292122.1
    XP_047292123.1
    XP_047292124.1
    XP_047292125.1
    XP_047292126.1
    XP_047292127.1
    XP_047292128.1
    XP_047292129.1
    XP_047292130.1
    XP_047292131.1
    XP_047292132.1
    XP_047292133.1
    XP_047292134.1
    XP_047292135.1
    XP_054172280.1
    XP_054172281.1
    XP_054172282.1
    XP_054172283.1
    XP_054172284.1
    XP_054172285.1
    XP_054172286.1
    XP_054172287.1
    XP_054172288.1
    XP_054172289.1
    XP_054172290.1
    XP_054172291.1
    XP_054172292.1
    XP_054172293.1
    XP_054172294.1
    XP_054172295.1
    XP_054172296.1
    XP_054172297.1
    XP_054172298.1
    XP_054172299.1
    XP_054172300.1
    XP_054172301.1
    XP_054172302.1
    XP_054172303.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028005.1 RefSeqGene

      Range
      5001..69722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024937.4NP_001020108.1  misshapen-like kinase 1 isoform 4

      See identical proteins and their annotated locations for NP_001020108.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini and is longer compared to isoform 1.
      Source sequence(s)
      AB041926, AL157418, AY775058, DA653105
      Consensus CDS
      CCDS45590.1
      UniProtKB/Swiss-Prot
      Q8N4C8
      Related
      ENSP00000406487.3, ENST00000453408.7
      Conserved Domains (3) summary
      smart00036
      Location:9941292
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    2. NM_001321236.2NP_001308165.1  misshapen-like kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AB041926, AL157418, BC094686, DA653105
      UniProtKB/Swiss-Prot
      Q8N4C8
      Conserved Domains (3) summary
      smart00036
      Location:9221220
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:11234
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1234
      PKc_like; Protein Kinases, catalytic domain
    3. NM_015716.5NP_056531.1  misshapen-like kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_056531.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
      Source sequence(s)
      AB035698, AB041926, AL157418, DA653105
      UniProtKB/Swiss-Prot
      Q8N4C8
      Conserved Domains (3) summary
      smart00036
      Location:9771275
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    4. NM_153827.5NP_722549.2  misshapen-like kinase 1 isoform 3

      See identical proteins and their annotated locations for NP_722549.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an additional in-frame exon, compared to variant 1, resulting in the longest isoform (3) which has a unique internal segment, compared to isoform 1.
      Source sequence(s)
      AB035698, AB041926, AL157418, BC034673, DA653105
      Consensus CDS
      CCDS45588.1
      UniProtKB/Swiss-Prot
      D3DTK3, D3DTK4, Q5U8Z0, Q8N4C8, Q9P1X1, Q9P2R8
      Related
      ENSP00000347427.6, ENST00000355280.11
      Conserved Domains (3) summary
      smart00036
      Location:10141312
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    5. NM_170663.5NP_733763.1  misshapen-like kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_733763.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an additional in-frame exon, compared to variant 1, resulting in a longer isoform (2) that has a unique internal segment, compared to isoform 1.
      Source sequence(s)
      AB041926, AL157418, DA653105
      Consensus CDS
      CCDS45589.1
      UniProtKB/Swiss-Prot
      Q8N4C8
      Related
      ENSP00000269296.7, ENST00000347992.11
      Conserved Domains (3) summary
      smart00036
      Location:9851283
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      4833340..4898061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721531.2XP_006721594.1  misshapen-like kinase 1 isoform X1

      Conserved Domains (3) summary
      smart00036
      Location:10431341
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    2. XM_006721532.2XP_006721595.1  misshapen-like kinase 1 isoform X2

      Conserved Domains (3) summary
      smart00036
      Location:10421340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    3. XM_006721536.2XP_006721599.1  misshapen-like kinase 1 isoform X11

      Conserved Domains (3) summary
      smart00036
      Location:10061304
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    4. XM_017024706.1XP_016880195.1  misshapen-like kinase 1 isoform X12

    5. XM_017024705.1XP_016880194.1  misshapen-like kinase 1 isoform X5

    6. XM_047436166.1XP_047292122.1  misshapen-like kinase 1 isoform X6

    7. XM_047436168.1XP_047292124.1  misshapen-like kinase 1 isoform X8

    8. XM_047436173.1XP_047292129.1  misshapen-like kinase 1 isoform X17

    9. XM_047436170.1XP_047292126.1  misshapen-like kinase 1 isoform X13

    10. XM_047436176.1XP_047292132.1  misshapen-like kinase 1 isoform X21

    11. XM_047436177.1XP_047292133.1  misshapen-like kinase 1 isoform X22

    12. XM_017024704.1XP_016880193.1  misshapen-like kinase 1 isoform X3

    13. XM_047436165.1XP_047292121.1  misshapen-like kinase 1 isoform X4

    14. XM_047436167.1XP_047292123.1  misshapen-like kinase 1 isoform X7

    15. XM_011523906.1XP_011522208.1  misshapen-like kinase 1 isoform X9

      Conserved Domains (3) summary
      smart00036
      Location:10111309
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
    16. XM_047436169.1XP_047292125.1  misshapen-like kinase 1 isoform X10

    17. XM_047436174.1XP_047292130.1  misshapen-like kinase 1 isoform X18

    18. XM_047436175.1XP_047292131.1  misshapen-like kinase 1 isoform X19

    19. XM_047436171.1XP_047292127.1  misshapen-like kinase 1 isoform X14

    20. XM_047436172.1XP_047292128.1  misshapen-like kinase 1 isoform X15

    21. XM_047436178.1XP_047292134.1  misshapen-like kinase 1 isoform X23

      Related
      ENST00000572330.5
    22. XM_047436179.1XP_047292135.1  misshapen-like kinase 1 isoform X24

    23. XM_017024708.2XP_016880197.1  misshapen-like kinase 1 isoform X20

    24. XM_017024707.3XP_016880196.1  misshapen-like kinase 1 isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      4722898..4788313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316305.1XP_054172280.1  misshapen-like kinase 1 isoform X1

    2. XM_054316306.1XP_054172281.1  misshapen-like kinase 1 isoform X2

    3. XM_054316315.1XP_054172290.1  misshapen-like kinase 1 isoform X11

    4. XM_054316316.1XP_054172291.1  misshapen-like kinase 1 isoform X12

    5. XM_054316309.1XP_054172284.1  misshapen-like kinase 1 isoform X5

    6. XM_054316310.1XP_054172285.1  misshapen-like kinase 1 isoform X6

    7. XM_054316312.1XP_054172287.1  misshapen-like kinase 1 isoform X8

    8. XM_054316321.1XP_054172296.1  misshapen-like kinase 1 isoform X17

    9. XM_054316317.1XP_054172292.1  misshapen-like kinase 1 isoform X13

    10. XM_054316325.1XP_054172300.1  misshapen-like kinase 1 isoform X21

    11. XM_054316326.1XP_054172301.1  misshapen-like kinase 1 isoform X22

    12. XM_054316307.1XP_054172282.1  misshapen-like kinase 1 isoform X3

    13. XM_054316308.1XP_054172283.1  misshapen-like kinase 1 isoform X4

    14. XM_054316311.1XP_054172286.1  misshapen-like kinase 1 isoform X7

    15. XM_054316313.1XP_054172288.1  misshapen-like kinase 1 isoform X9

    16. XM_054316314.1XP_054172289.1  misshapen-like kinase 1 isoform X10

    17. XM_054316322.1XP_054172297.1  misshapen-like kinase 1 isoform X18

    18. XM_054316323.1XP_054172298.1  misshapen-like kinase 1 isoform X19

    19. XM_054316318.1XP_054172293.1  misshapen-like kinase 1 isoform X14

    20. XM_054316319.1XP_054172294.1  misshapen-like kinase 1 isoform X15

    21. XM_054316327.1XP_054172302.1  misshapen-like kinase 1 isoform X23

    22. XM_054316328.1XP_054172303.1  misshapen-like kinase 1 isoform X24

    23. XM_054316320.1XP_054172295.1  misshapen-like kinase 1 isoform X16

    24. XM_054316324.1XP_054172299.1  misshapen-like kinase 1 isoform X20