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    EMI2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852128, updated on 22-Aug-2024

    Summary

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    Official Symbol
    EMI2
    Primary source
    FungiDB:YDR516C
    Locus tag
    YDR516C
    See related
    SGD:S000002924; AllianceGenome:SGD:S000002924; VEuPathDB:YDR516C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Involved in ascospore formation and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EMI2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1474974..1476476, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Slf1p Neighboring gene Grh1p Neighboring gene protein disulfide isomerase EUG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Emi2 Protein of Saccharomyces cerevisiae is a Hexokinase Expressed under Glucose Limitation. Umekawa M, et al. J Appl Glycosci (1999), 2020. PMID 34354536, Free PMC Article
    2. Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae. Lutfiyya LL, et al. Genetics, 1998 Dec. PMID 9832517, Free PMC Article
    3. Proteins That Interact with the Mucin-Type Glycoprotein Msb2p Include a Regulator of the Actin Cytoskeleton. Prabhakar A, et al. Biochemistry, 2019 Dec 3. PMID 31710471
    4. Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Enyenihi AH, et al. Genetics, 2003 Jan. PMID 12586695, Free PMC Article
    5. Chaperone-mediated pathway of proteasome regulatory particle assembly. Roelofs J, et al. Nature, 2009 Jun 11. PMID 19412159, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore formation HMP PubMed 
    involved_in carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organophosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative glucokinase
    NP_010804.3
    • Hexokinase expressed during growth with low glucose levels; induced on non-fermentable carbon sources; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; protein abundance increases in response to DNA replication stress; EMI2 has a paralog, GLK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1474974..1476476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180824.3 → NP_010804.3  TPA: putative glucokinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010804.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTD7, Q04409
      UniProtKB/TrEMBL
      A6ZZA3, B5VH37, C8Z672, G2WBP3, N1PAL7
      Conserved Domains (1) summary
      COG5026
      Location:1 → 500
      COG5026; Hexokinase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04409.1

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