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    GLYR1 glyoxylate reductase 1 homolog [ Homo sapiens (human) ]

    Gene ID: 84656, updated on 28-Oct-2024

    Summary

    Official Symbol
    GLYR1provided by HGNC
    Official Full Name
    glyoxylate reductase 1 homologprovided by HGNC
    Primary source
    HGNC:HGNC:24434
    See related
    Ensembl:ENSG00000140632 MIM:610660; AllianceGenome:HGNC:24434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NP60; NPAC; hNDF; BM045; HIBDL; N-PAC
    Summary
    Enables several functions, including chromatin-protein adaptor activity; methylated histone binding activity; and nucleosome binding activity. Involved in transcription elongation-coupled chromatin remodeling and transcription initiation-coupled chromatin remodeling. Located in cytosol and nucleoplasm. Part of nucleosome. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 23.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GLYR1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4803203..4847288, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4832757..4876778, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4853204..4897289, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene septin 12 Neighboring gene small integral membrane protein 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4852142-4852642 Neighboring gene Sharpr-MPRA regulatory region 4562 Neighboring gene rogdi atypical leucine zipper Neighboring gene uncharacterized LOC124903638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4897448-4898290 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:4901871-4903070 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:4908973-4910172 Neighboring gene ubinuclein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4920799-4920984 Neighboring gene MPRA-validated peak2474 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4935135-4935635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4945259-4946104 Neighboring gene uncharacterized LOC124903637 Neighboring gene periplakin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin-protein adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytokine-like nuclear factor N-PAC
    Names
    3-hydroxyisobutyrate dehydrogenase-like protein
    cytokine-like nuclear factor n-pac
    nuclear protein 60 kDa
    nuclear protein 60kDa
    nuclear protein NP60
    nuclear protein of 60 kDa
    nucleosome-destabilizing factor
    putative oxidoreductase GLYR1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308096.2NP_001295025.1  cytokine-like nuclear factor N-PAC isoform 2

      See identical proteins and their annotated locations for NP_001295025.1

      Status: VALIDATED

      Source sequence(s)
      AC020663, AF217521, AF326966, HY130375
      Consensus CDS
      CCDS81945.1
      UniProtKB/TrEMBL
      K7EMM8
      Related
      ENSP00000468328.1, ENST00000591451.5
      Conserved Domains (3) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:268545
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      pfam15376
      Location:110173
      DUF4603; Domain of unknown function (DUF4603)
    2. NM_001324096.2NP_001311025.2  cytokine-like nuclear factor N-PAC isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC020663, KF456151
      UniProtKB/TrEMBL
      K7EMM8
      Conserved Domains (2) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:187464
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    3. NM_001324097.2NP_001311026.2  cytokine-like nuclear factor N-PAC isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC020663, AK296842
      Consensus CDS
      CCDS92098.1
      UniProtKB/TrEMBL
      K7EMM8
      Related
      ENSP00000390276.4, ENST00000436648.9
      Conserved Domains (3) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:187470
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      cl21454
      Location:129221
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_001324098.2NP_001311027.2  cytokine-like nuclear factor N-PAC isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC020663, KF456151
      UniProtKB/TrEMBL
      K7EMM8
      Related
      ENSP00000466570.1, ENST00000589389.5
      Conserved Domains (3) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:251534
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      pfam15376
      Location:110173
      DUF4603; Domain of unknown function (DUF4603)
    5. NM_032569.4NP_115958.2  cytokine-like nuclear factor N-PAC isoform 1

      See identical proteins and their annotated locations for NP_115958.2

      Status: VALIDATED

      Source sequence(s)
      AF244907, CB529066, CK430984, CR933687, DB492328
      Consensus CDS
      CCDS10524.1
      UniProtKB/Swiss-Prot
      B4DL47, C9JJ40, C9JJ60, Q49A26, Q5U632, Q6P1Q2, Q6V3W7, Q9BTI1, Q9BXK2
      UniProtKB/TrEMBL
      K7EMM8
      Related
      ENSP00000322716.6, ENST00000321919.14
      Conserved Domains (4) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:268551
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      pfam15376
      Location:110173
      DUF4603; Domain of unknown function (DUF4603)
      cl21454
      Location:210302
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_136695.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020663, BC047223, BC064940
      Related
      ENST00000588732.5
    2. NR_136696.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020663, KF456151
    3. NR_136697.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020663, KF456151
    4. NR_136698.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020663, KF456151
    5. NR_136699.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020663, KF456151
    6. NR_136700.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC020663, KF456151

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      4803203..4847288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      4832757..4876778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)