U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PRE4 proteasome core particle subunit beta 7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850611, updated on 28-Oct-2024

    Summary

    Official Symbol
    PRE4
    Official Full Name
    proteasome core particle subunit beta 7
    Primary source
    SGD:S000001946
    Locus tag
    YFR050C
    See related
    AllianceGenome:SGD:S000001946; FungiDB:YFR050C; VEuPathDB:YFR050C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in proteasomal ubiquitin-independent protein catabolic process; proteasome assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, beta-subunit complex. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 3. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Oct 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRE4 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (249066..249866, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Rmd8p Neighboring gene alpha-ketoglutarate dehydrogenase subunit KGD4 Neighboring gene coatomer subunit delta Neighboring gene proteasome regulatory particle lid subunit RPN12

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, beta-subunit complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex, beta-subunit complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome core particle subunit beta 7
    NP_116708.1
    • Beta 7 subunit of the 20S proteasome

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      249066..249866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180015.1NP_116708.1  TPA: proteasome core particle subunit beta 7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116708.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTT3, E9P8Z8, P30657
      UniProtKB/TrEMBL
      A7A290, B3LUR1, B5VI75, C7GYF3, C8Z7Y5, G2WDJ1, N1P6J5
      Conserved Domains (1) summary
      cd03760
      Location:40236
      proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...