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    AMS1 alpha-mannosidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852721, updated on 2-Nov-2024

    Summary

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    Official Symbol
    AMS1
    Official Full Name
    alpha-mannosidase
    Primary source
    SGD:S000003124
    Locus tag
    YGL156W
    See related
    AllianceGenome:SGD:S000003124; FungiDB:YGL156W; VEuPathDB:YGL156W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-mannosidase activity. Involved in several processes, including cellular response to glucose starvation; cellular response to nitrogen starvation; and mannose catabolic process. Located in fungal-type vacuole membrane. Part of Cvt complex. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See AMS1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (210416..213667)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative serine/threonine protein kinase RCK1 Neighboring gene carbonyl reductase (NADPH-dependent) ARI1 Neighboring gene protein geranylgeranyltransferase type I subunit CDC43 Neighboring gene holo-[acyl-carrier-protein] synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural heterogeneity in the Man8-13GlcNAc oligosaccharides from log-phase Saccharomyces yeast: a one- and two-dimensional 1H NMR spectroscopic study. Trimble RB, et al. Glycobiology, 1992 Feb. PMID 1550991
    2. A novel pathway of import of alpha-mannosidase, a marker enzyme of vacuolar membrane, in Saccharomyces cerevisiae. Yoshihisa T, et al. J Biol Chem, 1990 Dec 25. PMID 2266133
    3. Nucleotide sequence of AMS1, the structure gene of vacuolar alpha-mannosidase of Saccharomyces cerevisiae. Yoshihisa T, et al. Biochem Biophys Res Commun, 1989 Sep 15. PMID 2675832
    4. Solubilization and purification of alpha-mannosidase, a marker enzyme of vacuolar membranes in Saccharomyces cerevisiae. Yoshihisa T, et al. J Biol Chem, 1988 Apr 15. PMID 3281936
    5. Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae. Hutchins MU, et al. J Biol Chem, 2001 Jun 8. PMID 11264288, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.
      Title: Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae.
    2. Atg34p and Atg19p have similar domain structures and are important for Ams1p transport during autophagy.
      Title: Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p.
    3. Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
      Title: Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
    4. AMS1 of Saccharomyces cerevisiae, a cargo protein of the Cvt pathway, was crystallized.
      Title: Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cvt complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-mannosidase
    NP_011359.1
    • Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; upregulated under glucose starvation; targeted to vacuole via CVT pathway and AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      210416..213667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181021.1 → NP_011359.1  TPA: alpha-mannosidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTZ5, P22855
      UniProtKB/TrEMBL
      N1P6H0
      Conserved Domains (1) summary
      COG0383
      Location:44 → 1083
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22855.2

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