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    ARD1 peptide alpha-N-acetyltransferase complex A subunit ARD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856404, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARD1
    Official Full Name
    peptide alpha-N-acetyltransferase complex A subunit ARD1
    Primary source
    SGD:S000001055
    Locus tag
    YHR013C
    See related
    AllianceGenome:SGD:S000001055; FungiDB:YHR013C; VEuPathDB:YHR013C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAA10
    Summary
    Contributes to peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation and N-terminal protein amino acid propionylation. Part of NatA complex. Used to study Ogden syndrome. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit) and NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ARD1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (130730..131446, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative serine--tRNA ligase DIA4 Neighboring gene retromer subunit VPS29 Neighboring gene Spo13p Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A strategy for the generation of conditional mutations by protein destabilization. Park EC, et al. Proc Natl Acad Sci U S A, 1992 Feb 15. PMID 1311090, Free PMC Article
    2. N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae. Varland S, et al. Mol Cell Proteomics, 2018 Dec. PMID 30150368, Free PMC Article
    3. The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Whiteway M, et al. Mol Cell Biol, 1987 Oct. PMID 3316986, Free PMC Article
    4. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Whiteway M, et al. Cell, 1985 Dec. PMID 3907857
    5. TEL+CEN antagonism on plasmids involves telomere repeat sequences tracts and gene products that interact with chromosomal telomeres. Enomoto S, et al. Chromosoma, 1994 Jul. PMID 7988285

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and mechanism of acetylation by the N-terminal dual enzyme NatA/Naa50 complex has been reported.
      Title: Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to peptide alpha-N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-serine-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-terminal protein amino acid acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-terminal protein amino acid acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in N-terminal protein amino acid propionylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptide alpha-N-acetyltransferase complex A subunit ARD1
    NP_011877.1
    • Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      130730..131446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179143.1 → NP_011877.1  TPA: peptide alpha-N-acetyltransferase complex A subunit ARD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011877.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKV8, P07347
      UniProtKB/TrEMBL
      A6ZSR7, B3LSD4, B5VJT8, C7GMP8, C8ZA80, G2WF81, N1P9K9
      Conserved Domains (1) summary
      COG0456
      Location:1 → 192
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07347.2

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