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    SPC97 Spc97p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856577, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SPC97
    Official Full Name
    Spc97p
    Primary source
    SGD:S000001215
    Locus tag
    YHR172W
    See related
    AllianceGenome:SGD:S000001215; FungiDB:YHR172W; VEuPathDB:YHR172W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables gamma-tubulin binding activity. Involved in cytoplasmic microtubule organization and microtubule nucleation. Located in inner plaque of spindle pole body and outer plaque of spindle pole body. Part of gamma-tubulin small complex. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SPC97 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (448335..450806)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosome-binding protein NMD3 Neighboring gene Atg7p Neighboring gene uncharacterized protein Neighboring gene phosphopyruvate hydratase ENO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization and orientation of the gamma-tubulin small complex components using protein tags as labels for single particle EM. Choy RM, et al. J Struct Biol, 2009 Dec. PMID 19723581, Free PMC Article
    2. The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. Knop M, et al. EMBO J, 1997 Apr 1. PMID 9130700, Free PMC Article
    3. Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. Friedman DB, et al. J Biol Chem, 2001 May 25. PMID 11278681, Free PMC Article
    4. The carboxy terminus of Tub4p is required for gamma-tubulin function in budding yeast. Vogel J, et al. J Cell Sci, 2000 Nov. PMID 11034914
    5. CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation. Brilot AF, et al. Elife, 2021 May 5. PMID 33949948, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gamma-tubulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin small complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin small complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in inner plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body HDA PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spc97p
    NP_012042.1
    • Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      448335..450806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179303.1 → NP_012042.1  TPA: Spc97p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012042.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLC1, P38863
      UniProtKB/TrEMBL
      N1P1A1
      Conserved Domains (2) summary
      pfam04130
      Location:560 → 652
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:60 → 410
      GCP_N_terminal; Gamma tubulin complex component N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38863.1

    Gene LinkOut

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