PEX2 ubiquitin-protein ligase peroxin 2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PEX2
Official Full Name: ubiquitin-protein ligase peroxin 2
Primary source: SGD:S000003746
Locus tag: YJL210W
See related: AllianceGenome:SGD:S000003746; FungiDB:YJL210W; VEuPathDB:YJL210W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CRT1; PAS5
Summary: Enables ubiquitin protein ligase activity. Involved in protein import into peroxisome matrix, receptor recycling; protein import into peroxisome matrix, substrate release; and protein monoubiquitination. Part of peroxisomal importomer complex. Is active in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 5B and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into peroxisome matrix, receptor recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into peroxisome matrix, receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix, substrate release	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of peroxisomal importomer complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

NP_012325.1

RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import

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The following sections contain reference sequences that belong to a specific genome build. Explain