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    IML1 GTPase-activating protein IML1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853603, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IML1
    Official Full Name
    GTPase-activating protein IML1
    Primary source
    SGD:S000003899
    Locus tag
    YJR138W
    See related
    AllianceGenome:SGD:S000003899; FungiDB:YJR138W; VEuPathDB:YJR138W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEA1
    Summary
    Enables GTPase activator activity. Involved in several processes, including cellular response to nitrogen starvation; negative regulation of intracellular signal transduction; and regulation of autophagosome assembly. Acts upstream of or within cellular response to oxidative stress. Located in fungal-type vacuole membrane. Part of GATOR1 complex. Used to study cancer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and familial focal epilepsy with variable foci 1. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See IML1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (684567..689321)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tti2p Neighboring gene sulfite reductase (NADPH) subunit beta Neighboring gene homoserine dehydrogenase Neighboring gene Hir3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation. Panchaud N, et al. Cell Cycle, 2013 Sep 15. PMID 23974112, Free PMC Article
    2. The SEACIT complex is involved in the maintenance of vacuole-mitochondria contact sites and controls mitophagy. Ma Y, et al. Cell Mol Life Sci, 2019 Apr. PMID 30673821, Free PMC Article
    3. Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation. Wu X, et al. Mol Biol Cell, 2011 Nov. PMID 21900499, Free PMC Article
    4. GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle. Chen J, et al. Nat Chem Biol, 2017 Nov. PMID 28920930, Free PMC Article
    5. Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae. Sekiguchi T, et al. Biochem Biophys Res Commun, 2022 Apr 2. PMID 35158208

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upon amino acid deprivation, Iml1 transiently interacts with Gtr1 at the vacuolar membrane stimulating its intrinsic GTPase activity, thus decreasing the activity of TORC1.
      Title: Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.
    2. Iml1p contains a conserved domain that is required for non-nitrogen starvation-induced autophagy as well as complex formation
      Title: Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GATOR1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GATOR1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein IML1
    NP_012672.1
    • GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy, and is a subcomplex of the SEA, a coatomer-related complex that associates with the vacuole; Iml1p functions as a GAP for the Rag family GTPase Gtr1p (EGOC subunit) in SEACIT, resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; role in the oxidative stress response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      684567..689321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181796.2 → NP_012672.1  TPA: GTPase-activating protein IML1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWV7, P47170
      UniProtKB/TrEMBL
      A6ZQ94, N1P8Y1
      Conserved Domains (2) summary
      cd04449
      Location:1188 → 1271
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:208 → 484
      IML1; Vacuolar membrane-associated protein Iml1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47170.1

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