U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    XYL2 D-xylulose reductase XYL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850759, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    XYL2
    Official Full Name
    D-xylulose reductase XYL2
    Primary source
    SGD:S000004060
    Locus tag
    YLR070C
    See related
    AllianceGenome:SGD:S000004060; FungiDB:YLR070C; VEuPathDB:YLR070C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-xylulose reductase activity. Involved in xylulose biosynthetic process. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Oct 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See XYL2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (274141..275211, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fyv7p Neighboring gene Mef1p Neighboring gene Rgr1p Neighboring gene Lam6p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression of different levels of enzymes from the Pichia stipitis XYL1 and XYL2 genes in Saccharomyces cerevisiae and its effects on product formation during xylose utilisation. Walfridsson M, et al. Appl Microbiol Biotechnol, 1997 Aug. PMID 9299780
    2. Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase. Richard P, et al. FEBS Lett, 1999 Aug 20. PMID 10486580
    3. Repeated-batch fermentations of xylose and glucose-xylose mixtures using a respiration-deficient Saccharomyces cerevisiae engineered for xylose metabolism. Kim SR, et al. J Biotechnol, 2010 Nov. PMID 20933550
    4. Optimizing the coordinated transcription of central xylose-metabolism genes in Saccharomyces cerevisiae. Zhang X, et al. Appl Microbiol Biotechnol, 2018 Aug. PMID 29946930
    5. Impact of overexpressing NADH kinase on glucose and xylose metabolism in recombinant xylose-utilizing Saccharomyces cerevisiae. Hou J, et al. Appl Microbiol Biotechnol, 2009 Apr. PMID 19221731

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-xylulose reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-xylulose reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arabinose catabolic process to xylulose 5-phosphate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sorbitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    D-xylulose reductase XYL2
    NP_013171.1
    • Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      274141..275211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181957.1 → NP_013171.1  TPA: D-xylulose reductase XYL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY71, Q07993
      UniProtKB/TrEMBL
      A7A0X5, B3LT40, B5VN02, C7GQP5, C8ZD42, G2WIR2, N1NZI2
      Conserved Domains (1) summary
      cd05285
      Location:9 → 354
      sorbitol_DH; Sorbitol dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07993.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools