U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SAM1 methionine adenosyltransferase SAM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850877, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SAM1
    Official Full Name
    methionine adenosyltransferase SAM1
    Primary source
    SGD:S000004170
    Locus tag
    YLR180W
    See related
    AllianceGenome:SGD:S000004170; FungiDB:YLR180W; VEuPathDB:YLR180W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ETH10
    Summary
    Enables methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and methionine metabolic process. Acts upstream of or within negative regulation of stress granule assembly. Located in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to several human genes including MAT1A (methionine adenosyltransferase 1A). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SAM1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (515262..516410)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Tfs1p Neighboring gene uncharacterized protein Neighboring gene Vta1p Neighboring gene transcriptional regulator SWI6

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Random mutagenesis and recombination of sam1 gene by integrating error-prone PCR with staggered extension process. An Y, et al. Biotechnol Lett, 2008 Jul. PMID 18317700
    2. Antigenic conservation of primary structural regions of S-adenosylmethionine synthetase. Kotb M, et al. Biochim Biophys Acta, 1990 Sep 3. PMID 1698095
    3. Effects of regulatory mutations upon methionine biosynthesis in Saccharomyces cerevisiae: loci eth2-eth3-eth10. Cherest H, et al. J Bacteriol, 1973 Sep. PMID 4580557, Free PMC Article
    4. SAM1, the structural gene for one of the S-adenosylmethionine synthetases in Saccharomyces cerevisiae. Sequence and expression. Thomas D, et al. J Biol Chem, 1987 Dec 5. PMID 3316224
    5. Identification and functional reconstitution of yeast mitochondrial carrier for S-adenosylmethionine. Marobbio CM, et al. EMBO J, 2003 Nov 17. PMID 14609944, Free PMC Article

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAM1 and SAM2 have different effects on genome stability through distinctive effects on gene expression and AdoMet levels.
      Title: Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine adenosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine adenosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    methionine adenosyltransferase SAM1
    NP_013281.1
    • S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      515262..516410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182067.1 → NP_013281.1  TPA: methionine adenosyltransferase SAM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013281.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYI4, P10659
      UniProtKB/TrEMBL
      A7A171, B3RH72, B5VN99, C7GIW9, N1NYC1
      Conserved Domains (1) summary
      cd18079
      Location:6 → 378
      S-AdoMet_synt; S-adenosylmethionine synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10659.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools