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    TAD3 Tad3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851027, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TAD3
    Official Full Name
    Tad3p
    Primary source
    SGD:S000004308
    Locus tag
    YLR316C
    See related
    AllianceGenome:SGD:S000004308; FungiDB:YLR316C; VEuPathDB:YLR316C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA-specific adenosine deaminase activity. Involved in tRNA modification. Located in peroxisome. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TAD3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    3
    Sequence:
    Chromosome: XII; NC_001144.5 (765266..766358, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sph1p Neighboring gene septin CDC3 Neighboring gene Nkp2p Neighboring gene telomerase reverse transcriptase Neighboring gene Bud6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism, specificity and general properties of the yeast enzyme catalysing the formation of inosine 34 in the anticodon of transfer RNA. Auxilien S, et al. J Mol Biol, 1996 Oct 4. PMID 8893855
    2. The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae. Wada M, et al. FEBS J, 2023 Jul. PMID 36806932
    3. Crystal structure of the yeast heterodimeric ADAT2/3 deaminase. Liu X, et al. BMC Biol, 2020 Dec 3. PMID 33272269, Free PMC Article
    4. An adenosine deaminase that generates inosine at the wobble position of tRNAs. Gerber AP, et al. Science, 1999 Nov 5. PMID 10550050
    5. Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast. Lada AG, et al. Biochemistry (Mosc), 2011 Jan. PMID 21568845, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CGA codon decoding through tRNA[Arg] (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
      Title: The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
    2. Crystal structure of the ADAT2-ADAT3 heterodimer. [ADAT2, ADAT3]
      Title: Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tad3p
    NP_013420.2
    • Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; localizes to cytosol, nucleus and peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      765266..766358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182205.1 → NP_013420.2  TPA: Tad3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013420.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYW0, O13552, Q9URQ3
      UniProtKB/TrEMBL
      G2WJD9
      Conserved Domains (1) summary
      COG0590
      Location:149 → 318
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9URQ3.1

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