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    Uqcc1 ubiquinol-cytochrome c reductase complex assembly factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683512, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Uqcc1provided by RGD
    Official Full Name
    ubiquinol-cytochrome c reductase complex assembly factor 1provided by RGD
    Primary source
    RGD:1585681
    See related
    EnsemblRapid:ENSRNOG00000048309 AllianceGenome:RGD:1585681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Uqcc
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in cytoplasmic vesicle and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human UQCC1 (ubiquinol-cytochrome c reductase complex assembly factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 337.6), Muscle (RPKM 167.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uqcc1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164813398..164905892, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144353276..144445810, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151384965..151474112, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 6 Neighboring gene family with sequence similarity 83, member C Neighboring gene uncharacterized LOC134486190 Neighboring gene growth differentiation factor 5 Neighboring gene centrosomal protein 250 Neighboring gene similar to human chromosome 20 open reading frame 173

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of a novel mouse gene 'mbFZb' in distinct regions of the developing nervous system and the adult brain. Vetter K, et al. Mech Dev, 2001 Jan. PMID 11118897
    2. Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression. Tucker EJ, et al. PLoS Genet, 2013. PMID 24385928, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquinol-cytochrome c reductase complex assembly factor 1
    Names
    ubiquinol-cytochrome c reductase complex chaperone

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109446.2 → NP_001102916.1  ubiquinol-cytochrome c reductase complex assembly factor 1

      See identical proteins and their annotated locations for NP_001102916.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107807
      UniProtKB/TrEMBL
      A0A8I6G7D8, M0RAB6, Q32Q54
      Related
      ENSRNOP00000066461.1, ENSRNOT00000072679.4
      Conserved Domains (1) summary
      pfam03981
      Location:136 → 275
      Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      164813398..164905892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105862.1 → XP_038961790.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G7D8
      Conserved Domains (1) summary
      pfam03981
      Location:155 → 290
      Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

    2. XM_039105861.2 → XP_038961789.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X2

      UniProtKB/TrEMBL
      A6KI69
      Conserved Domains (1) summary
      pfam03981
      Location:37 → 172
      Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone

    3. XM_039105859.2 → XP_038961787.1  ubiquinol-cytochrome c reductase complex assembly factor 1 isoform X1

      Conserved Domains (1) summary
      pfam03981
      Location:136 → 195
      Ubiq_cyt_C_chap; Ubiquinol-cytochrome C chaperone
    Nucleotide Protein Strain
    Heading Accession and Version

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