Slc38a1 solute carrier family 38, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc38a1provided by RGD
Official Full Name: solute carrier family 38, member 1provided by RGD
Primary source: RGD:69645
See related: EnsemblRapid:ENSRNOG00000005291 AllianceGenome:RGD:69645
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ata1; GlnT; Sat1
Summary: Enables alanine:sodium symporter activity; glycine:sodium symporter activity; and proline:sodium symporter activity. Involved in several processes, including amino acid import; glutamine metabolic process; and positive regulation of L-glutamine import across plasma membrane. Located in external side of apical plasma membrane and neuronal cell body. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SLC38A1 (solute carrier family 38 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 285.3), Thymus (RPKM 191.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q35

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (129612414..129681727, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (127733230..127802541, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (137970555..138040098, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming
Title: Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells
Title: Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine.
Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in rat cardiomyocytes.
Title: Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in freshly isolated rat cardiomyocytes.
SNAT1/SAT1 is the amino acid transporter system member that plays a critical role in dynamically modulating inhibition in response to metabolic demands.
Title: Activity- and age-dependent modulation of GABAergic neurotransmission by system A-mediated glutamine uptake.
SNAT1 protein expression decreased in the liver and intestine shortly after birth and as the rat matured; SNAT1 expression was constant throughout development in the lungs and kidney and increased in the heart from prenatal day 19 to postnatal day 2
Title: Ontogeny of the neutral amino acid transporter SNAT1 in the developing rat.
A high-capacity imino acid carrier localized at the small intestinal luminal membrane that transports nutrients and amino acids and imino acids.
Title: H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.
Immunohistochemistry demonstrates the presence of SNAT1 within the placental labyrinth and within fetal endothelium.
Title: SNAT expression in rat placenta.
GlnT expression is upregulated by cyclic AMP/protein kinase A signals for subsequent exacerbation of the vulnerability to oxidative stress in astrocytes.
Title: Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes.
distribution of SNAT1 in central nervous system neurons and characterization of its transport properties
Title: Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons.

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General gene information

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Markers

RH130789 (e-PCR)
- UniSTS:214073

RH131580 (e-PCR)
- UniSTS:214863

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables alanine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proline:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-alpha-amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in alanine transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid import	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in gamma-aminobutyric acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glutamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycine transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of L-glutamine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-coupled neutral amino acid symporter 1

Names: N-system amino acid transporter 2; amino acid transporter A1; amino acid transporter system A1; glutamine transporter; rATA1; sodium-coupled neutral amino acid transporter 1; system A amino acid transporter 1; system A transporter 2; system N amino acid transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138832.1 → NP_620187.1 sodium-coupled neutral amino acid symporter 1

See identical proteins and their annotated locations for NP_620187.1

Status: PROVISIONAL

Source sequence(s)

AF075704

UniProtKB/Swiss-Prot

Q9JM15

UniProtKB/TrEMBL

A6KC24

Related

ENSRNOP00000008138.4, ENSRNOT00000008138.6

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

129612414..129681727 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242281.5 → XP_006242343.1 sodium-coupled neutral amino acid symporter 1 isoform X1

See identical proteins and their annotated locations for XP_006242343.1

UniProtKB/Swiss-Prot

Q9JM15

UniProtKB/TrEMBL

A6KC24

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063262935.1 → XP_063119005.1 sodium-coupled neutral amino acid symporter 1 isoform X1

UniProtKB/Swiss-Prot

Q9JM15

UniProtKB/TrEMBL

A6KC24
XM_006242280.5 → XP_006242342.1 sodium-coupled neutral amino acid symporter 1 isoform X1

See identical proteins and their annotated locations for XP_006242342.1

UniProtKB/Swiss-Prot

Q9JM15

UniProtKB/TrEMBL

A6KC24

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006242277.5 → XP_006242339.1 sodium-coupled neutral amino acid symporter 1 isoform X1

See identical proteins and their annotated locations for XP_006242339.1

UniProtKB/Swiss-Prot

Q9JM15

UniProtKB/TrEMBL

A6KC24

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063262936.1 → XP_063119006.1 sodium-coupled neutral amino acid symporter 1 isoform X1

UniProtKB/Swiss-Prot

Q9JM15

UniProtKB/TrEMBL

A6KC24
XM_039078321.2 → XP_038934249.1 sodium-coupled neutral amino acid symporter 1 isoform X2

Conserved Domains (1) summary

cl00456
Location:3 → 341

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain