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    Ehbp1 EH domain binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305556, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ehbp1provided by RGD
    Official Full Name
    EH domain binding protein 1provided by RGD
    Primary source
    RGD:1310604
    See related
    EnsemblRapid:ENSRNOG00000008917 AllianceGenome:RGD:1310604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310604
    Summary
    Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Orthologous to human EHBP1 (EH domain binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 186.9), Brain (RPKM 142.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ehbp1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (100294585..100581764, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (96093327..96380502, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (106871426..107160224, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481800 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene orthodenticle homeobox 1 Neighboring gene hornerin-like Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene Neighboring gene uncharacterized LOC134481801 Neighboring gene uncharacterized LOC134481802 Neighboring gene transmembrane protein 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation. Ji Y, et al. J Neurosci, 2024 Feb 7. PMID 38129132, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
      Title: EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EH domain-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305130.1 → NP_001292059.1  EH domain-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      F1LVX2
      Related
      ENSRNOP00000012131.8, ENSRNOT00000012131.9
      Conserved Domains (4) summary
      pfam00307
      Location:427 → 523
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1041 → 1181
      DUF3585; Protein of unknown function (DUF3585)
      cl01251
      Location:928 → 1012
      OHCU_decarbox; OHCU decarboxylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      100294585..100581764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273264.1 → XP_063129334.1  EH domain-binding protein 1 isoform X11

    2. XM_063273263.1 → XP_063129333.1  EH domain-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZZB4
      Related
      ENSRNOP00000083406.1, ENSRNOT00000096295.2

    3. XM_017599244.3 → XP_017454733.1  EH domain-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LVX2
      Conserved Domains (4) summary
      pfam00307
      Location:427 → 523
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1044 → 1184
      DUF3585; Protein of unknown function (DUF3585)
      cl01251
      Location:928 → 1012
      OHCU_decarbox; OHCU decarboxylase

    4. XM_063273262.1 → XP_063129332.1  EH domain-binding protein 1 isoform X9

    5. XM_063273257.1 → XP_063129327.1  EH domain-binding protein 1 isoform X6

    6. XM_063273258.1 → XP_063129328.1  EH domain-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKB4

    7. XM_006251565.3 → XP_006251627.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006251627.1

      UniProtKB/TrEMBL
      F1LVX2
      Conserved Domains (4) summary
      pfam00307
      Location:427 → 523
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1044 → 1184
      DUF3585; Protein of unknown function (DUF3585)
      cl01251
      Location:928 → 1012
      OHCU_decarbox; OHCU decarboxylase

    8. XM_008770445.4 → XP_008768667.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008768667.1

      UniProtKB/TrEMBL
      F1LVX2
      Related
      ENSRNOP00000107146.1, ENSRNOT00000157515.1
      Conserved Domains (4) summary
      pfam00307
      Location:427 → 523
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1044 → 1184
      DUF3585; Protein of unknown function (DUF3585)
      cl01251
      Location:928 → 1012
      OHCU_decarbox; OHCU decarboxylase

    9. XM_063273261.1 → XP_063129331.1  EH domain-binding protein 1 isoform X8

    10. XM_063273259.1 → XP_063129329.1  EH domain-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKB4

    11. XM_063273253.1 → XP_063129323.1  EH domain-binding protein 1 isoform X3

    12. XM_063273255.1 → XP_063129325.1  EH domain-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AC10

    13. XM_063273252.1 → XP_063129322.1  EH domain-binding protein 1 isoform X2

    14. XM_063273251.1 → XP_063129321.1  EH domain-binding protein 1 isoform X1

    15. XM_006251568.3 → XP_006251630.1  EH domain-binding protein 1 isoform X9

      See identical proteins and their annotated locations for XP_006251630.1

      UniProtKB/TrEMBL
      F1LVX2
      Conserved Domains (4) summary
      pfam00307
      Location:351 → 447
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:968 → 1108
      DUF3585; Protein of unknown function (DUF3585)
      cl01251
      Location:852 → 936
      OHCU_decarbox; OHCU decarboxylase

    16. XM_063273260.1 → XP_063129330.1  EH domain-binding protein 1 isoform X8

    17. XM_039092088.2 → XP_038948016.1  EH domain-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKB4, F1LVX2
      Conserved Domains (4) summary
      COG1196
      Location:833 → 1109
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:980 → 1108
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:389 → 495
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    18. XM_063273256.1 → XP_063129326.1  EH domain-binding protein 1 isoform X5

    19. XM_006251566.3 → XP_006251628.1  EH domain-binding protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006251628.1

      UniProtKB/TrEMBL
      F1LVX2
      Related
      ENSRNOP00000077506.2, ENSRNOT00000095555.2
      Conserved Domains (4) summary
      pfam00307
      Location:392 → 488
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1009 → 1149
      DUF3585; Protein of unknown function (DUF3585)
      cl01251
      Location:893 → 977
      OHCU_decarbox; OHCU decarboxylase

    20. XM_006251567.3 → XP_006251629.1  EH domain-binding protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006251629.1

      UniProtKB/TrEMBL
      A0A8I6AC10, F1LVX2
      Related
      ENSRNOP00000090221.1, ENSRNOT00000114018.2
      Conserved Domains (4) summary
      pfam00307
      Location:427 → 523
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1008 → 1148
      DUF3585; Protein of unknown function (DUF3585)
      cl01251
      Location:892 → 976
      OHCU_decarbox; OHCU decarboxylase

    21. XM_063273265.1 → XP_063129335.1  EH domain-binding protein 1 isoform X12

    22. XM_039092087.2 → XP_038948015.1  EH domain-binding protein 1 isoform X12

      Conserved Domains (3) summary
      COG1196
      Location:399 → 676
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12130
      Location:547 → 675
      DUF3585; Protein of unknown function (DUF3585)
      cl00030
      Location:1 → 26
      CH_SF; calponin homology (CH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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