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    Slc12a6 solute carrier family 12, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691209, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc12a6provided by RGD
    Official Full Name
    solute carrier family 12, member 6provided by RGD
    Primary source
    RGD:1311335
    See related
    EnsemblRapid:ENSRNOG00000005196 AllianceGenome:RGD:1311335
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kcc3
    Summary
    Predicted to enable potassium:chloride symporter activity and protein kinase binding activity. Predicted to be involved in several processes, including cellular hypotonic salinity response; cellular response to glucose stimulus; and monoatomic ion transmembrane transport. Predicted to be located in axon and basolateral plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and agenesis of the corpus callosum with peripheral neuropathy. Orthologous to human SLC12A6 (solute carrier family 12 member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 168.5), Spleen (RPKM 167.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc12a6 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119525521..119624655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99071577..99170266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (103752213..103852686)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NUT midline carcinoma, family member 1 Neighboring gene NOP10 ribonucleoprotein Neighboring gene 60S ribosomal protein L19-like Neighboring gene ER membrane protein complex subunit 4 Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene ER membrane protein complex subunit 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. High-grade glioma motility reduced by genetic knockdown of KCC3. Gagnon KB. Cell Physiol Biochem, 2012. PMID 22776998
    2. Role of cholesterol in functional association between K(+)-Cl(-) cotransporter-3a and Na+,K(+)-ATPase. Fujita K, et al. Biochem Biophys Res Commun, 2012 Jul 20. PMID 22732406
    3. The NH(2)-terminus of K(+)-Cl(-) cotransporter 3a is essential for up-regulation of Na(+),K(+)-ATPase activity. Fujii T, et al. Biochem Biophys Res Commun, 2010 Sep 3. PMID 20691666
    4. K+-Cl- Cotransporter-3a Up-regulates Na+,K+-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells. Fujii T, et al. J Biol Chem, 2008 Mar 14. PMID 18178552
    5. KCC3 and KCC4 expression in rat adult forebrain. Le Rouzic P, et al. Brain Res, 2006 Sep 19. PMID 16872584

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data are consistent with a role for KCC3 in the proximal tubule glucose reabsorption mechanism.
      Title: Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
    2. Genetic silencing of KCC3 with short hairpin interfering RNA reduced protein expression by 40 - 60%, K(+) influx by ~50%, and cell motility by ~50%.
      Title: High-grade glioma motility reduced by genetic knockdown of KCC3.
    3. these results suggest that cholesterol is essential for eliciting up-regulation of Na(+),K(+)-ATPase activity by KCC3a in the KCC3a-alpha1NaK complex.
      Title: Role of cholesterol in functional association between K(+)-Cl(-) cotransporter-3a and Na+,K(+)-ATPase.
    4. these results suggest that the NH(2)-terminus of KCC3a is a key region for association with alpha1NaK, and that KCC3a but not KCC3b can regulate the Na(+),K(+)-ATPase activity.
      Title: The NH(2)-terminus of K(+)-Cl(-) cotransporter 3a is essential for up-regulation of Na(+),K(+)-ATPase activity.
    5. KCC3a forms a functional complex with alpha1NaK in the basolateral membrane of luminal parietal cells, and it up-regulates alpha1NaK in lipid rafts, whereas KCC3a is absent in basal parietal cells
      Title: K+-Cl- Cotransporter-3a Up-regulates Na+,K+-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells.
    6. distribution of KCC1, KCC3a, KCC3b, KCC4, and KCC2 protein and mrna in pancreatic alpha-cells and beta-cells; KCC's make a significant contribution to volume homeostasis only in alpha-cells
      Title: Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas.
    7. show a more restricted expression of KCC3a in the hippocampus, choroid plexus and piriform cortex.
      Title: KCC3 and KCC4 expression in rat adult forebrain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular hypotonic response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular hypotonic salinity response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 12 member 6
    Names
    furosemide-sensitive KCl cotransporter 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109630.1 → NP_001103100.1  solute carrier family 12 member 6

      See identical proteins and their annotated locations for NP_001103100.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HP46, G3V6N7
      Related
      ENSRNOP00000084986.2, ENSRNOT00000099025.2
      Conserved Domains (3) summary
      TIGR00930
      Location:109 → 1150
      2a30; K-Cl cotransporter
      pfam03522
      Location:774 → 1150
      SLC12; Solute carrier family 12
      cl00456
      Location:209 → 360
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      119525521..119624655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284594.1 → XP_063140664.1  solute carrier family 12 member 6 isoform X1

      UniProtKB/TrEMBL
      A6HP46

    2. XM_006234710.5 → XP_006234772.1  solute carrier family 12 member 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZ36, G3V6N7
      Related
      ENSRNOP00000007144.7, ENSRNOT00000007144.8
      Conserved Domains (3) summary
      TIGR00930
      Location:94 → 1135
      2a30; K-Cl cotransporter
      pfam03522
      Location:759 → 1135
      SLC12; Solute carrier family 12
      cl00456
      Location:194 → 345
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006234711.5 → XP_006234773.1  solute carrier family 12 member 6 isoform X3

      See identical proteins and their annotated locations for XP_006234773.1

      UniProtKB/TrEMBL
      A0A8I5Y638, A0A8I6A5L1, A6HP47
      Related
      ENSRNOP00000073931.3, ENSRNOT00000079727.3
      Conserved Domains (3) summary
      TIGR00930
      Location:58 → 1099
      2a30; K-Cl cotransporter
      pfam03522
      Location:723 → 1099
      SLC12; Solute carrier family 12
      cl00456
      Location:158 → 309
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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