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    Prss40 protease, serine, 40 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316318, updated on 2-Nov-2024

    Summary

    Official Symbol
    Prss40provided by RGD
    Official Full Name
    protease, serine, 40provided by RGD
    Primary source
    RGD:1561330
    See related
    EnsemblRapid:ENSRNOG00000014001 AllianceGenome:RGD:1561330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tesp2; RGD1561330
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 37.2) See more
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    Genomic context

    See Prss40 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44258081..44266893, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36762170..36770979, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41061116..41069929, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene protease, serine, 39 Neighboring gene cripto, FRL-1, cryptic family 1 Neighboring gene small nucleolar RNA, H/ACA box 51 Neighboring gene RCC1 and BTB domain containing protein 1, pseudogene 1 Neighboring gene APC membrane recruitment protein 3 Neighboring gene thymosin beta-10-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    serine protease 40
    Names
    testicular serine protease 2
    NP_001101679.1
    XP_038939487.1
    XP_063123213.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108209.1NP_001101679.1  serine protease 40 precursor

      See identical proteins and their annotated locations for NP_001101679.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A6INA6, D3ZR46
      Related
      ENSRNOP00000018758.5, ENSRNOT00000018758.7
      Conserved Domains (2) summary
      smart00020
      Location:70310
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:71313
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      44258081..44266893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083559.2XP_038939487.1  serine protease 40 isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:2199
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_063267143.1XP_063123213.1  serine protease 40 isoform X1