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    Duoxa1 dual oxidase maturation factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Duoxa1provided by RGD
    Official Full Name
    dual oxidase maturation factor 1provided by RGD
    Primary source
    RGD:1306601
    See related
    EnsemblRapid:ENSRNOG00000018005 AllianceGenome:RGD:1306601
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306601
    Summary
    Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of hydrogen peroxide biosynthetic process and protein localization. Predicted to act upstream of or within several processes, including hydrogen peroxide metabolic process; positive regulation of reactive oxygen species metabolic process; and regulation of thyroid hormone generation. Predicted to be located in cell leading edge; endoplasmic reticulum; and plasma membrane. Predicted to be active in membrane. Orthologous to human DUOXA1 (dual oxidase maturation factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 18.0), Uterus (RPKM 8.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Duoxa1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (129703416..129714110, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (109249815..109260511, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (114241057..114251720, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dual oxidase 2 Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase 1 Neighboring gene Src homology 2 domain containing F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Delimitation and functional characterization of the bidirectional THOX-DUOXA promoter regions in thyrocytes. Christophe-Hobertus C, et al. Mol Cell Endocrinol, 2010 Apr 12. PMID 20060878
    2. Mice deficient in dual oxidase maturation factors are severely hypothyroid. Grasberger H, et al. Mol Endocrinol, 2012 Mar. PMID 22301785, Free PMC Article
    3. Dual oxidase regulates neutrophil recruitment in allergic airways. Chang S, et al. Free Radic Biol Med, 2013 Dec. PMID 23770197, Free PMC Article
    4. The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA. Hoste C, et al. Exp Cell Res, 2012 Nov 1. PMID 22814254
    5. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. Luxen S, et al. J Cell Sci, 2009 Apr 15. PMID 19339556, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual oxidase maturation factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107767.1 → NP_001101237.1  dual oxidase maturation factor 1

      See identical proteins and their annotated locations for NP_001101237.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I6GA32, A6HPS9, D3ZEH0
      Conserved Domains (1) summary
      pfam10204
      Location:11 → 282
      DuoxA; Dual oxidase maturation factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      129703416..129714110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104980.2 → XP_038960908.1  dual oxidase maturation factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA32, A6HPS9, D3ZEH0
      Conserved Domains (1) summary
      pfam10204
      Location:11 → 282
      DuoxA; Dual oxidase maturation factor

    2. XM_006234857.4 → XP_006234919.1  dual oxidase maturation factor 1 isoform X2

      See identical proteins and their annotated locations for XP_006234919.1

      UniProtKB/TrEMBL
      A0A8I6GA32, A6HPS9, D3ZEH0
      Conserved Domains (1) summary
      pfam10204
      Location:11 → 282
      DuoxA; Dual oxidase maturation factor

    3. XM_039104978.2 → XP_038960906.1  dual oxidase maturation factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA32, A6HPS9, D3ZEH0
      Conserved Domains (1) summary
      pfam10204
      Location:11 → 282
      DuoxA; Dual oxidase maturation factor

    4. XM_039104977.2 → XP_038960905.1  dual oxidase maturation factor 1 isoform X1

      Conserved Domains (1) summary
      pfam10204
      Location:117 → 326
      DuoxA; Dual oxidase maturation factor

    5. XM_039104979.2 → XP_038960907.1  dual oxidase maturation factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA32, A6HPS9, D3ZEH0
      Related
      ENSRNOP00000024246.3, ENSRNOT00000024245.6
      Conserved Domains (1) summary
      pfam10204
      Location:11 → 282
      DuoxA; Dual oxidase maturation factor
    Nucleotide Protein Strain
    Heading Accession and Version

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