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    Pex1 peroxisomal biogenesis factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500006, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pex1provided by RGD
    Official Full Name
    peroxisomal biogenesis factor 1provided by RGD
    Primary source
    RGD:1559939
    See related
    EnsemblRapid:ENSRNOG00000025991 AllianceGenome:RGD:1559939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559939
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ubiquitin-modified protein reader activity. Predicted to be involved in protein import into peroxisome matrix, receptor recycling; protein targeting to peroxisome; and protein unfolding. Predicted to act upstream of or within microtubule-based peroxisome localization. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 1; peroxisome biogenesis disorder 1A; and peroxisome biogenesis disorder 1B. Orthologous to human PEX1 (peroxisomal biogenesis factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 155.1), Adrenal (RPKM 140.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pex1 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (31474670..31513621, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (30519950..30558953, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27659376..27698037, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane BAX inhibitor motif containing 7 Neighboring gene GATA zinc finger domain containing 1 Neighboring gene RIKEN cDNA 1700109H08 gene like Neighboring gene RNA binding motif protein 48 Neighboring gene family with sequence similarity 133, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Liver disease predominates in a mouse model for mild human Zellweger spectrum disorder. Berendse K, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Oct 1. PMID 31207289
    2. Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression. Jurado Acosta A, et al. Cell Tissue Res, 2017 Feb. PMID 27826738
    3. The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Hiebler S, et al. Mol Genet Metab, 2014 Apr. PMID 24503136, Free PMC Article
    4. A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p. Tamura S, et al. Biochem Biophys Res Commun, 1998 Apr 28. PMID 9588209
    5. Phenotype-genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p-Pex6p interaction. Tamura S, et al. Biochem J, 2001 Jul 15. PMID 11439091, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PEX1 activation of the MMP-9 promoter triggers the pro-fibrotic response directed by PEX1.
      Title: Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within microtubule-based peroxisome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based peroxisome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome matrix, receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein unfolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein unfolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal ATPase PEX1
    Names
    peroxisome biogenesis factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109220.1 → NP_001102690.1  peroxisomal ATPase PEX1

      See identical proteins and their annotated locations for NP_001102690.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474013
      UniProtKB/TrEMBL
      A0A8I6ADS4, A6K285, D3ZZB2
      Related
      ENSRNOP00000093891.2, ENSRNOT00000104070.2
      Conserved Domains (4) summary
      smart00382
      Location:877 → 1009
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:877 → 1006
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09262
      Location:104 → 179
      PEX-1N; Peroxisome biogenesis factor 1, N-terminal
      pfam09263
      Location:19 → 98
      PEX-2N; Peroxisome biogenesis factor 1, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      31474670..31513621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236054.4 → XP_006236116.1  peroxisomal ATPase PEX1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALA5
      Conserved Domains (2) summary
      smart00382
      Location:717 → 849
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:717 → 846
      AAA; ATPase family associated with various cellular activities (AAA)

    2. XM_039108094.2 → XP_038964022.1  peroxisomal ATPase PEX1 isoform X2

      Conserved Domains (1) summary
      TIGR01243
      Location:60 → 525
      CDC48; AAA family ATPase, CDC48 subfamily

    3. XM_039108095.2 → XP_038964023.1  peroxisomal ATPase PEX1 isoform X3

      Conserved Domains (3) summary
      pfam00004
      Location:595 → 686
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09262
      Location:104 → 179
      PEX-1N; Peroxisome biogenesis factor 1, N-terminal
      pfam09263
      Location:17 → 98
      PEX-2N; Peroxisome biogenesis factor 1, N-terminal

    RNA

    1. XR_005503290.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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