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    Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54287, updated on 2-Nov-2024

    Summary

    Official Symbol
    Eif2ak2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 2-alpha kinase 2provided by RGD
    Primary source
    RGD:3402
    See related
    EnsemblRapid:ENSRNOG00000048315 AllianceGenome:RGD:3402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pkr; Prkr
    Summary
    Predicted to enable double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including response to exogenous dsRNA; response to lipopolysaccharide; and response to vitamin E. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia 33; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 178.3), Lung (RPKM 134.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eif2ak2 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21941147..21977115)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16189000..16224972)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1428845..1466193, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein F, pseudogene 4 Neighboring gene keratin-associated protein 5-1-like Neighboring gene sulfotransferase family 6B member 1 Neighboring gene uncharacterized LOC120103477 Neighboring gene G patch domain containing 11 Neighboring gene HEAT repeat containing 5B Neighboring gene striatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hematopoietic progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hematopoietic stem cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translational initiation by eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to exogenous dsRNA IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to interferon-alpha IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to vitamin E IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    interferon-induced, double-stranded RNA-activated protein kinase
    Names
    Protein kinase, interferon-inducible double stranded RNA dependent
    eIF-2A protein kinase 2
    interferon-inducible RNA-dependent protein kinase
    protein kinase R
    protein kinase RNA-activated
    tyrosine-protein kinase EIF2AK2
    NP_062208.2
    XP_008762647.2
    XP_038968708.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019335.2NP_062208.2  interferon-induced, double-stranded RNA-activated protein kinase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q63184
      UniProtKB/TrEMBL
      A0A0G2K100, A6H9V3
      Related
      ENSRNOP00000088431.1, ENSRNOT00000111754.2
      Conserved Domains (3) summary
      cd19903
      Location:774
      DSRM_EIF2AK2_rpt1; first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cd19904
      Location:94160
      DSRM_EIF2AK2_rpt2; second double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cl21453
      Location:229498
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      21941147..21977115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112780.2XP_038968708.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X2

      UniProtKB/Swiss-Prot
      Q63184
      Related
      ENSRNOP00000067694.4, ENSRNOT00000072810.4
      Conserved Domains (3) summary
      cd19903
      Location:774
      DSRM_EIF2AK2_rpt1; first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cd19904
      Location:94160
      DSRM_EIF2AK2_rpt2; second double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cl21453
      Location:229455
      PKc_like; Protein Kinases, catalytic domain
    2. XM_008764425.2XP_008762647.2  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q63184
      UniProtKB/TrEMBL
      A0A0G2K100, A6H9V3
      Related
      ENSRNOP00000085948.1, ENSRNOT00000119285.2
      Conserved Domains (3) summary
      cd19903
      Location:774
      DSRM_EIF2AK2_rpt1; first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cd19904
      Location:94160
      DSRM_EIF2AK2_rpt2; second double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cl21453
      Location:229498
      PKc_like; Protein Kinases, catalytic domain