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    HXT2 hexose transporter HXT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855023, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HXT2
    Official Full Name
    hexose transporter HXT2
    Primary source
    SGD:S000004613
    Locus tag
    YMR011W
    See related
    AllianceGenome:SGD:S000004613; FungiDB:YMR011W; VEuPathDB:YMR011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-glucose transmembrane transporter activity and pentose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HXT2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (288079..289704)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene acireductone dioxygenase (Ni2+-requiring) Neighboring gene Any1p Neighboring gene tRNA-Glu Neighboring gene translation initiation factor 3 subunit CLU1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification by comprehensive chimeric analysis of a key residue responsible for high affinity glucose transport by yeast HXT2. Kasahara T, et al. J Biol Chem, 2007 May 4. PMID 17369259
    2. Transmembrane segment 10 is important for substrate recognition in Ga12 and Hxt2 sugar transporters in the yeast Saccharomyces cerevisiae. Kasahara M, et al. FEBS Lett, 1996 Jul 1. PMID 8766824
    3. Rapid kinetics of glucose uptake in Saccharomyces cerevisiae. Walsh MC, et al. Folia Microbiol (Praha), 1994. PMID 8550023
    4. The amino-terminal tail of Hxt11 confers membrane stability to the Hxt2 sugar transporter and improves xylose fermentation in the presence of acetic acid. Shin HY, et al. Biotechnol Bioeng, 2017 Sep. PMID 28464256, Free PMC Article
    5. Physiological characterization of putative high-affinity glucose transport protein Hxt2 of Saccharomyces cerevisiae by use of anti-synthetic peptide antibodies. Wendell DL, et al. J Bacteriol, 1993 Dec. PMID 8244939, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The increased D-xylose affinity could be related to the C terminus, more specifically to a cysteine to proline mutation at position 505 in Hxt2.
      Title: Increased xylose affinity of Hxt2 through gene shuffling of hexose transporters in Saccharomyces cerevisiae.
    2. findings suggest that the general activity of RNAP III can indirectly affect the RNAP II transcriptional machinery on the HXT2 promoter when cellular perception transduced via the major signaling pathways, broadly recognized as on/off switch essential to either positive or negative HXT gene regulation, remain entirely intact
      Title: Low RNA Polymerase III activity results in up regulation of HXT2 glucose transporter independently of glucose signaling and despite changing environment.
    3. Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
      Title: Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
    4. In addition to leucine 201 (TM5), four residues of Hxt2 (leucine 59 and leucine 61 in TM1, asparagine 331 in TM7, and phenylalanine 366 in TM8) were found to be important for high affinity transport
      Title: Eight amino acid residues in transmembrane segments of yeast glucose transporter Hxt2 are required for high affinity transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables pentose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hexose transporter HXT2
    NP_013724.1
    • High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      288079..289704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182507.1 → NP_013724.1  TPA: hexose transporter HXT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZI5, P23585
      UniProtKB/TrEMBL
      A6ZM72, B3LLR2, B5VPD7, C7GLA8, C8ZEL7, E9P9G5, N1P5B7
      Conserved Domains (1) summary
      pfam00083
      Location:59 → 519
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23585.1

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