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    THI12 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855384, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THI12
    Official Full Name
    4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
    Primary source
    SGD:S000005276
    Locus tag
    YNL332W
    See related
    AllianceGenome:SGD:S000005276; FungiDB:YNL332W; VEuPathDB:YNL332W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity and transferase activity. Involved in thiamine biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See THI12 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (14832..15854)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene pyridoxine biosynthesis protein SNZ2 Neighboring gene putative aryl-alcohol dehydrogenase Neighboring gene histone deacetylase RPD3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
    2. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873
    3. Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. van Pel DM, et al. G3 (Bethesda), 2013 Feb. PMID 23390603, Free PMC Article
    4. The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Wightman R, et al. Microbiology (Reading), 2003 Jun. PMID 12777485
    5. Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Rodríguez-Navarro S, et al. Yeast, 2002 Oct. PMID 12271461

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thiamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
    NP_014067.1
    • Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      14832..15854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183170.1 → NP_014067.1  TPA: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0L5, P42883
      UniProtKB/TrEMBL
      C8ZGJ3
      Conserved Domains (1) summary
      cd13650
      Location:5 → 255
      PBP2_THI5; Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42883.1

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