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    CSR2 Csr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856142, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CSR2
    Official Full Name
    Csr2p
    Primary source
    SGD:S000006234
    Locus tag
    YPR030W
    See related
    AllianceGenome:SGD:S000006234; FungiDB:YPR030W; VEuPathDB:YPR030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ART8; MRG19
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in fungal-type cell wall organization and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CSR2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (627880..631245)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Yop1p Neighboring gene Apl4p Neighboring gene Nto1p Neighboring gene Rab GTPase-binding protein SRO7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The efficiency of mitochondrial electron transport chain is increased in the long-lived mrg19 Saccharomyces cerevisiae. Mittal N, et al. Aging Cell, 2009 Dec. PMID 19732042
    2. Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence. Kharade SV, et al. FEBS Lett, 2005 Dec 19. PMID 16336970
    3. Disruption of MRG19 results in altered nitrogen metabolic status and defective pseudohyphal development in Saccharomyces cerevisiae. Das M, et al. Microbiology (Reading), 2005 Jan. PMID 15632429
    4. Molecular characterization of MRG19 of Saccharomyces cerevisiae. Implication in the regulation of galactose and nonfermentable carbon source utilization. Khanday FA, et al. Eur J Biochem, 2002 Dec. PMID 12444972
    5. Multiple copies of MRG19 suppress transcription of the GAL1 promoter in a GAL80-dependent manner in Saccharomyces cerevisiae. Kabir MA, et al. Mol Gen Genet, 2000 Jan. PMID 10660072

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two glucose signaling pathways converge onto Csr2 to regulate hexose transporter Hxt6 endocytosis by glucose availability.
      Title: Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis.
    2. find that mrg19 mitochondria have higher expression of electron transport chain components per mitochondria in comparison with the wild type.
      Title: The efficiency of mitochondrial electron transport chain is increased in the long-lived mrg19 Saccharomyces cerevisiae.
    3. studies revealed that MRG19 regulates carbon and nitrogen metabolism, as well as morphogenetic changes, suggesting that MRG19 is a component of the link between the metabolic status of the cell and the corresponding developmental pathway
      Title: Disruption of MRG19 results in altered nitrogen metabolic status and defective pseudohyphal development in Saccharomyces cerevisiae.
    4. Ubp2 modulates Lys(63)-polyubiquitination of Rsp5 substrates in vivo, including ubiquitination of two newly identified Rsp5 substrates, Csr2 and Ecm21
      Title: The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae.
    5. Mrg19 depletion increases S cerevisiae lifespan by augmenting ROS defense.
      Title: Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent endocytosis ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Csr2p
    NP_015355.1
    • Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      627880..631245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184127.1 → NP_015355.1  TPA: Csr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015355.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W440, Q12734
      UniProtKB/TrEMBL
      A6ZWS3, B3LL91, C7GQA8, C8ZJ54, N1NVJ6
      Conserved Domains (2) summary
      smart01017
      Location:638 → 737
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl02844
      Location:828 → 926
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12734.1

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