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    ARP7 Arp7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856146, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARP7
    Official Full Name
    Arp7p
    Primary source
    SGD:S000006238
    Locus tag
    YPR034W
    See related
    AllianceGenome:SGD:S000006238; FungiDB:YPR034W; VEuPathDB:YPR034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RSC11; SWP61
    Summary
    Predicted to enable chromatin binding activity. Involved in nucleosome disassembly; positive regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in nucleus. Part of RSC-type complex and SWI/SNF complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to human ACTL6A (actin like 6A) and ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ARP7 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (639525..640958)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene histidine--tRNA ligase Neighboring gene glutamate--ammonia ligase Neighboring gene H(+)-transporting V1 sector ATPase subunit H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF. Cairns BR, et al. Mol Cell, 1998 Nov. PMID 9844636
    2. Structure of the full-length yeast Arp7-Arp9 heterodimer. Lobsiger J, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531465
    3. The Swi2/Snf2 bromodomain is required for the displacement of SAGA and the octamer transfer of SAGA-acetylated nucleosomes. Hassan AH, et al. J Biol Chem, 2006 Jun 30. PMID 16648632
    4. The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action. Prescott TA, et al. Phytochemistry, 2014 May. PMID 24569176
    5. Allosteric interactions of DNA and nucleotides with S. cerevisiae RSC. Malik SS, et al. Biochemistry, 2011 Sep 20. PMID 21834590, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a function for subunit Rtt102 as a stabilizing factor for the Arp7/9 heterodime
      Title: Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular non-membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arp7p
    NP_015359.1
    • Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      639525..640958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184131.1 → NP_015359.1  TPA: Arp7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W444, Q12406
      UniProtKB/TrEMBL
      A6ZWS7, B3LL95, B5VTJ2, C7GQA4, C8ZJ58, G2WPL2, N1NVJ7
      Conserved Domains (1) summary
      COG5277
      Location:1 → 471
      COG5277; Actin-related protein [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12406.1

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