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    PKH3 protein kinase PKH3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852077, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PKH3
    Official Full Name
    protein kinase PKH3
    Primary source
    SGD:S000002874
    Locus tag
    YDR466W
    See related
    AllianceGenome:SGD:S000002874; FungiDB:YDR466W; VEuPathDB:YDR466W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in cell integrity MAPK cascade. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PDPK1 (3-phosphoinositide dependent protein kinase 1) and PDPK2P (3-phosphoinositide dependent protein kinase 2, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PKH3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1395121..1397817)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Spp41p Neighboring gene protein-arginine N5-methyltransferase Neighboring gene Tlg1p Neighboring gene Sdc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response. Pastor-Flores D, et al. BMC Genomics, 2015 Sep 21. PMID 26391581, Free PMC Article
    2. PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Inagaki M, et al. Mol Cell Biol, 1999 Dec. PMID 10567559, Free PMC Article
    3. Cell cycle-dependent phosphorylation of Sec4p controls membrane deposition during cytokinesis. Lepore D, et al. J Cell Biol, 2016 Sep 12. PMID 27621363, Free PMC Article
    4. A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability. Messier V, et al. Cell, 2013 May 23. PMID 23706744
    5. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell integrity MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase PKH3
    NP_010754.1
    • Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1395121..1397817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180774.1 → NP_010754.1  TPA: protein kinase PKH3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT91, Q03306
      UniProtKB/TrEMBL
      A6ZZ57, B3LFJ8, B5VGZ6, C7GKQ8, C8Z625, G2WBJ7, N1PAK7
      Conserved Domains (1) summary
      cd05581
      Location:9 → 293
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03306.1

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