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    OST2 dolichyl-diphosphooligosaccharide-protein glycotransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854270, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OST2
    Official Full Name
    dolichyl-diphosphooligosaccharide-protein glycotransferase
    Primary source
    SGD:S000005629
    Locus tag
    YOR103C
    See related
    AllianceGenome:SGD:S000005629; FungiDB:YOR103C; VEuPathDB:YOR103C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase complex. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OST2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (516449..516841, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene carnitine:acyl carnitine antiporter Neighboring gene Ras family GTPase RAS1 Neighboring gene Pin2p Neighboring gene uncharacterized protein Neighboring gene SNAP receptor VAM3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast cell death caused by mutation of the OST2 gene encoding the epsilon-subunit of Saccharomyces cerevisiae oligosaccharyltransferase. Sugiura M, et al. Biosci Biotechnol Biochem, 2006 May. PMID 16717427
    2. Defects in N-glycosylation induce apoptosis in yeast. Hauptmann P, et al. Mol Microbiol, 2006 Feb. PMID 16420350
    3. The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms. Silberstein S, et al. J Cell Biol, 1995 Oct. PMID 7593165, Free PMC Article
    4. A dual affinity tag on the 64-kDa Nlt1p subunit allows the rapid characterization of mutant yeast oligosaccharyl transferase complexes. Pathak R, et al. Arch Biochem Biophys, 1997 Feb 1. PMID 9015380
    5. The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides. Kelleher DJ, et al. J Biol Chem, 1994 Apr 29. PMID 8175708

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Apoptosis-like cell death in ost2 mutants is caused by the secondary effect of overall reduced protein N-linked glycosylation.
      Title: Yeast cell death caused by mutation of the OST2 gene encoding the epsilon-subunit of Saccharomyces cerevisiae oligosaccharyltransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oligosaccharyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide-protein glycotransferase
    NP_014746.2
    • Non-catalytic epsilon subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Wbp1p involved in binding terminal glucose units of the donor glycan; located in the ER lumen

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      516449..516841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183522.1 → NP_014746.2  TPA: dolichyl-diphosphooligosaccharide-protein glycotransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014746.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2G3, P46964
      UniProtKB/TrEMBL
      A6ZNV2, B3LJE8, C7GMN2, G2WMX9, N1NVS4
      Conserved Domains (1) summary
      pfam02109
      Location:24 → 130
      DAD; DAD family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46964.3

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