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    TINCR TINCR ubiquitin domain containing [ Homo sapiens (human) ]

    Gene ID: 257000, updated on 10-Oct-2024

    Summary

    Official Symbol
    TINCRprovided by HGNC
    Official Full Name
    TINCR ubiquitin domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:14607
    See related
    Ensembl:ENSG00000223573 MIM:615241; AllianceGenome:HGNC:14607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TUBL; PLAC2; LINC00036; NCRNA00036; onco-lncRNA-16
    Summary
    This gene produces a spliced long non-coding RNA that binds RNAs. This transcript interacts with staufen-1 protein to regulate the stability of mRNAs for genes involved in the differentiation of epidermal tissue. Variation in this gene may be associated with cancer progression. [provided by RefSeq, Aug 2017]
    Expression
    Biased expression in skin (RPKM 41.2), placenta (RPKM 9.2) and 1 other tissue See more
    Orthologs
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    Genomic context

    See TINCR in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5558167..5567953, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5544852..5554635, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5558178..5567964, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc and ring finger 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51701 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5477057-5477274 Neighboring gene uncharacterized LOC124904622 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:5498934-5499766 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5512941-5513440 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5526673-5527573 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5536495-5537158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5537159-5537822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5560556-5561352 Neighboring gene Sharpr-MPRA regulatory regions 733 and 12449 Neighboring gene SNRPE pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5589167-5589789 Neighboring gene scaffold attachment factor B2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:5611821-5613020 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5621326-5622058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9924 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:5622792-5623524

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    TINCR ubiquitin domain containing
    Names
    TINCR-encoded ubiquitin-like protein
    long intergenic non-protein coding RNA 36
    placenta-specific 2 (non-protein coding)
    terminal differentiation-induced ncRNA
    tissue differentiation-inducing non-protein coding RNA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396408.1NP_001383337.1  TINCR ubiquitin domain containing isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC011533
      Consensus CDS
      CCDS92495.1
      UniProtKB/TrEMBL
      A0A1B0GTR7, A0A1B0GVN0
      Related
      ENSP00000490584.1, ENST00000448587.6
      Conserved Domains (1) summary
      cl28922
      Location:1683
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. NM_001396409.1NP_001383338.1  TINCR ubiquitin domain containing isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC011533
      Consensus CDS
      CCDS92496.1
      UniProtKB/Swiss-Prot
      A0A2R8Y7D0
      Related
      ENSP00000496189.1, ENST00000646160.1
      Conserved Domains (1) summary
      cl28922
      Location:1683
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      5558167..5567953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      5544852..5554635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153375.1: Suppressed sequence

      Description
      NM_153375.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.