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    MRN1 Mrn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855917, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MRN1
    Official Full Name
    Mrn1p
    Primary source
    SGD:S000006105
    Locus tag
    YPL184C
    See related
    AllianceGenome:SGD:S000006105; FungiDB:YPL184C; VEuPathDB:YPL184C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PTR69
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in several processes, including 3'-UTR-mediated mRNA destabilization; cellular response to cell wall damage; and mRNA splicing, via spliceosome. Located in P-body and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MRN1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (195950..197788, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mf(Alpha)1p Neighboring gene Uip4p Neighboring gene putative mitochondrial 54S ribosomal protein RTC6 Neighboring gene Rtt10p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function. Reynaud K, et al. PLoS Genet, 2021 Apr. PMID 33857138, Free PMC Article
    2. Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system. Hogan DJ, et al. PLoS Biol, 2008 Oct 28. PMID 18959479, Free PMC Article
    3. MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation. Düring L, et al. PLoS One, 2012. PMID 23028530, Free PMC Article
    4. Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies. Moldavski O, et al. Dev Cell, 2015 Jun 8. PMID 26004510
    5. Emergence and evolution of yeast prion and prion-like proteins. An L, et al. BMC Evol Biol, 2016 Jan 25. PMID 26809710, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
      Title: Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
    2. MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.
      Title: MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in 3'-UTR-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cell wall damage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to cell wall damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mrn1p
    NP_015140.1
    • mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and destabilizes these mRNAs during stress, acting antagonistically to Nab6p; links cell wall homeostasis to mitochondrial structure and function; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      195950..197788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183998.1 → NP_015140.1  TPA: Mrn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015140.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I4, Q08925
      UniProtKB/TrEMBL
      A6ZW69, B3LKP4, C7GJD3, N1P2N7
      Conserved Domains (4) summary
      cd12520
      Location:200 → 273
      RRM1_MRN1; RNA recognition motif 1 (RRM1) found in RNA-binding protein MRN1 and similar proteins
      cd12521
      Location:430 → 503
      RRM3_MRN1; RNA recognition motif 3 (RRM3) found in RNA-binding protein MRN1 and similar proteins
      cd12523
      Location:289 → 372
      RRM2_MRN1; RNA recognition motif 2 (RRM2) found in RNA-binding protein MRN1 and similar proteins
      cl17169
      Location:519 → 606
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08925.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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