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    FAF1 Faf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854793, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FAF1
    Official Full Name
    Faf1p
    Primary source
    SGD:S000001281
    Locus tag
    YIL019W
    See related
    AllianceGenome:SGD:S000001281; FungiDB:YIL019W; VEuPathDB:YIL019W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FAF1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (315093..316133)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II core subunit RPB3 Neighboring gene 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 Neighboring gene ribosomal 60S subunit protein L2B Neighboring gene glucose-induced degradation complex subunit VID28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, interacts with factors of both the 60 S and the 40 s ribosomal subunit assembly. Shirai C, et al. J Biol Chem, 2004 Jun 11. PMID 15078877
    2. Functional and physical interactions of Faf1p, a Saccharomyces cerevisiae nucleolar protein. Karkusiewicz I, et al. Biochem Biophys Res Commun, 2004 Jun 25. PMID 15178413
    3. Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast. Zheng S, et al. J Biol Chem, 2014 Aug 15. PMID 24990943, Free PMC Article
    4. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. Yamada H, et al. RNA, 2007 Nov. PMID 17804645, Free PMC Article
    5. Cryo-EM structure of 90S small ribosomal subunit precursors in transition states. Du Y, et al. Science, 2020 Sep 18. PMID 32943522

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results illustrate the versatility of KH domains in protein interaction and provide insight into the role of Krr1-Faf1 interaction in ribosome biogenesis.
      Title: Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Faf1p
    NP_012245.1
    • Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      315093..316133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179369.1 → NP_012245.1  TPA: Faf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVR0, P40546, Q6Q5G5
      UniProtKB/TrEMBL
      A6ZVP8, B3LTM7, B5VKS2, C7GPW7, C8ZAN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40546.1

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