U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LIFR-AS1 LIFR antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100506495, updated on 17-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LIFR-AS1provided by HGNC
    Official Full Name
    LIFR antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:43600
    See related
    Ensembl:ENSG00000244968 AllianceGenome:HGNC:43600
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in thyroid (RPKM 1.5), brain (RPKM 1.4) and 23 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LIFR-AS1 in Genome Data Viewer
    Location:
    5p13.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (38556786..38671216)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (38805863..38920283)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (38556888..38671318)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene EGF like, fibronectin type III and laminin G domains Neighboring gene uncharacterized LOC105374732 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:38463193-38464392 Neighboring gene uncharacterized LOC124900964 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:38466368-38467567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38468935-38469806 Neighboring gene LIF receptor subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38556889-38557672 Neighboring gene uncharacterized LOC105374735 Neighboring gene microRNA 3650 Neighboring gene Sharpr-MPRA regulatory region 9095 Neighboring gene OSMR divergent transcript Neighboring gene long intergenic non-protein coding RNA 1265 Neighboring gene transmembrane protein 126A pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer. Song P, et al. Clin Epigenetics, 2022 Oct 31. PMID 36316703, Free PMC Article
    2. LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma. Liu F, et al. J Clin Lab Anal, 2022 Aug. PMID 35778954, Free PMC Article
    3. Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers. Bai Z, et al. Biomed Res Int, 2022. PMID 35071590, Free PMC Article
    4. M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling. Chen JQ, et al. Cell Cycle, 2021 Dec. PMID 34658294, Free PMC Article
    5. High long non-coding LIFR-AS1 expression correlates with poor survival in gastric carcinoma. Wang HF, et al. Eur Rev Med Pharmacol Sci, 2020 May. PMID 32495872

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer.
      Title: Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer.
    2. LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma.
      Title: LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma.
    3. Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers.
      Title: Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers.
    4. Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis.
      Title: Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis.
    5. M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling.
      Title: M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling.
    6. Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-kappaB pathway in glioma.
      Title: Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-κB pathway in glioma.
    7. lncRNA LIFRAS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR4698.
      Title: lncRNA LIFR‑AS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR‑4698.
    8. High long non-coding LIFR-AS1 expression correlates with poor survival in gastric carcinoma.
      Title: High long non-coding LIFR-AS1 expression correlates with poor survival in gastric carcinoma.
    9. LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer.
      Title: LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer.
    10. LIFR-AS1 serves as a competitive endogenous RNA for miR-29a to inhibit its expression and up-regulate downstream target TNFAIP3 expression, finally modulating the resistance of colorectal cancer to pohotodynamic therapy.
      Title: Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Other Names

    • CTD-2196P11.1
    • LIFR antisense RNA 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_103553.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC010425, AC091823
      Related
      ENST00000500733.6

    2. NR_103554.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains multiple alternate 3' exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC091823, BC045578

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      38556786..38671216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      38805863..38920283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials