Slc25a46 solute carrier family 25, member 46 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a46provided by RGD
Official Full Name: solute carrier family 25, member 46provided by RGD
Primary source: RGD:1305072
See related: EnsemblRapid:ENSRNOG00000017091 AllianceGenome:RGD:1305072
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305072
Summary: Predicted to be involved in axon development and mitochondrial membrane fission. Predicted to act upstream of or within several processes, including autophagy of mitochondrion; locomotion involved in locomotory behavior; and nervous system development. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human SLC25A46 (solute carrier family 25 member 46). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 178.2), Heart (RPKM 172.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (23490422..23519599, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (23215954..23244917, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (24369104..24397412, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells.
Title: SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132912 (e-PCR)
- UniSTS:216195

RH129924 (e-PCR)
- UniSTS:213212

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebellar Purkinje cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial membrane fission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within optic nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system neuron axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory chain complex IV assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial outer membrane protein SLC25A46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100515.1 → NP_001093985.1 mitochondrial outer membrane protein SLC25A46

Status: PROVISIONAL

Source sequence(s)

BC166810

UniProtKB/Swiss-Prot

Q5EB62

UniProtKB/TrEMBL

B2RYK4

Related

ENSRNOP00000023032.5, ENSRNOT00000023032.8

Conserved Domains (1) summary

pfam00153
Location:317 → 402

Mito_carr; Mitochondrial carrier protein