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    Gys2 glycogen synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25623, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gys2provided by RGD
    Official Full Name
    glycogen synthase 2provided by RGD
    Primary source
    RGD:2773
    See related
    EnsemblRapid:ENSRNOG00000059753 AllianceGenome:RGD:2773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GLYSN
    Summary
    Enables D-glucose binding activity and alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in glycogen biosynthetic process and response to glucose. Located in cortical actin cytoskeleton and cytosol. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 213.1), Thymus (RPKM 72.0) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gys2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177096063..177137236, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175365054..175406228, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176638632..176679805, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene golgi transport 1B Neighboring gene spexin hormone Neighboring gene lactate dehydrogenase B Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Control of liver glycogen synthase activity and intracellular distribution by phosphorylation. Ros S, et al. J Biol Chem, 2009 Mar 6. PMID 19124463
    2. Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytes. Kadotani A, et al. Arch Biochem Biophys, 2007 Oct 15. PMID 17880910
    3. Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling. Fang Y, et al. Mol Pharmacol, 2007 Apr. PMID 17200418
    4. Purification and characterization of the glycogen-bound protein phosphatase from rat liver. Wera S, et al. J Biol Chem, 1991 Jan 5. PMID 1898724
    5. The primary structure of rat liver glycogen synthase deduced by cDNA cloning. Absence of phosphorylation sites 1a and 1b. Bai G, et al. J Biol Chem, 1990 May 15. PMID 2110561

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transgenic LGS rat showed enhanced glycogen storage and an mproved glucose tolerance.
      Title: Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.
    2. LGS translocation is strictly dependent on glycogen synthesis.
      Title: Control of liver glycogen synthase activity and intracellular distribution by phosphorylation.
    3. elevation of glycogen synthase activity has an inhibitory effect on glucose production in hepatocytes by shunting gluconeogenic precursors into glycogen.
      Title: Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytes.
    4. bile acids are physiological regulators of glycogen synthase in rat liver and conjugated bile acids use a Galpha(i)-coupled G protein-coupled receptor to regulate GS activity in vitro and in vivo
      Title: Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
    5. glycogen synthase is activated by glucose-6-phosphate, which also controls its subcellular distribution in the hepatocyte
      Title: Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to glucose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycogen [starch] synthase, liver
    Names
    Glycogen synthase 2 (liver)
    NP_037221.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013089.2 → NP_037221.2  glycogen [starch] synthase, liver

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P17625, Q99MF8
      UniProtKB/TrEMBL
      D4A5K9
      Related
      ENSRNOP00000074743.1, ENSRNOT00000090122.3
      Conserved Domains (2) summary
      cd03793
      Location:27 → 615
      GT1_Glycogen_synthase_GSY2_like; Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the ...
      pfam05693
      Location:32 → 660
      Glycogen_syn; Glycogen synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      177096063..177137236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17625.2 GenPept UniProtKB/Swiss-Prot:P17625

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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