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    PI15 peptidase inhibitor 15 [ Homo sapiens (human) ]

    Gene ID: 51050, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PI15provided by HGNC
    Official Full Name
    peptidase inhibitor 15provided by HGNC
    Primary source
    HGNC:HGNC:8946
    See related
    Ensembl:ENSG00000137558 MIM:607076; AllianceGenome:HGNC:8946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P24TI; P25TI; CRISP8
    Summary
    This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in appendix (RPKM 36.9), prostate (RPKM 13.1) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PI15 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (74824534..74855029)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (75254011..75284508)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (75736769..75767264)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MIR2052 host gene Neighboring gene long intergenic non-protein coding RNA 3071 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:75560326-75560913 Neighboring gene microRNA 2052 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:75720049-75720586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:75859985-75860622 Neighboring gene cysteine rich secretory protein LCCL domain containing 1 Neighboring gene uncharacterized LOC124901964 Neighboring gene uncharacterized LOC105375905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:76042510-76043087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma. Jiang Y, et al. EBioMedicine, 2019 Feb. PMID 30638862, Free PMC Article
    2. Peptidase Inhibitor 15 (PI15) Regulates Chlamydial CPAF Activity. Prusty BK, et al. Front Cell Infect Microbiol, 2018. PMID 29900129, Free PMC Article
    3. cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. Yamakawa T, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473672
    4. Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. Koshikawa N, et al. J Biochem, 1996 Feb. PMID 8882727
    5. A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor. Kaplan F, et al. Am J Physiol, 1999 Jun. PMID 10362728

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686F0366

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidase inhibitor 15
    Names
    25 kDa trypsin inhibitor
    CRISP-8
    PI-15
    cysteine-rich secretory protein 8
    protease inhibitor 15
    sugarCrisp

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324403.2 → NP_001311332.1  peptidase inhibitor 15 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC011632, AC026616
      Consensus CDS
      CCDS6218.1
      UniProtKB/Swiss-Prot
      O43692, Q68CY1
      Related
      ENSP00000497041.1, ENST00000649643.1
      Conserved Domains (1) summary
      cd18814
      Location:67 → 212
      CAP_PI15; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15

    2. NM_015886.5 → NP_056970.1  peptidase inhibitor 15 preproprotein

      See identical proteins and their annotated locations for NP_056970.1

      Status: REVIEWED

      Source sequence(s)
      AC011632, AC026616, CR749657, D45027
      Consensus CDS
      CCDS6218.1
      UniProtKB/Swiss-Prot
      O43692, Q68CY1
      Related
      ENSP00000260113.2, ENST00000260113.7
      Conserved Domains (1) summary
      cd18814
      Location:67 → 212
      CAP_PI15; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      74824534..74855029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      75254011..75284508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43692.1 GenPept UniProtKB/Swiss-Prot:O43692

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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