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    LTB4R2 leukotriene B4 receptor 2 [ Homo sapiens (human) ]

    Gene ID: 56413, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LTB4R2provided by HGNC
    Official Full Name
    leukotriene B4 receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:19260
    See related
    Ensembl:ENSG00000213906 MIM:605773; AllianceGenome:HGNC:19260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLT2; NOP9; BLTR2; JULF2; KPG_004; LTB4-R2; LTB4-R 2
    Summary
    Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in skin (RPKM 12.7), spleen (RPKM 9.3) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LTB4R2 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24310140..24312038)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18508483..18510381)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24779346..24781244)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TGM1 promoter region Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8209 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:24747863-24748093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8210 Neighboring gene NOP9 nucleolar protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8213 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene dehydrogenase/reductase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5636 Neighboring gene cell death inducing DFFA like effector b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24785286-24785786 Neighboring gene leukotriene B4 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24790818-24791777 Neighboring gene adenylate cyclase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5639 Neighboring gene Sharpr-MPRA regulatory region 10023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8216 Neighboring gene receptor interacting serine/threonine kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Targeting of the BLT2 in chronic myeloid leukemia inhibits leukemia stem/progenitor cell function. Xiao M, et al. Biochem Biophys Res Commun, 2016 Apr 15. PMID 26966074
    2. Up-regulation of BLT2 is critical for the survival of bladder cancer cells. Seo JM, et al. Exp Mol Med, 2011 Mar 31. PMID 21252614, Free PMC Article
    3. UVB radiation induces apoptosis in keratinocytes by activating a pathway linked to "BLT2-reactive oxygen species". Ryu HC, et al. J Invest Dermatol, 2010 Apr. PMID 20090768
    4. Leukotriene BLT2 receptor monomers activate the G(i2) GTP-binding protein more efficiently than dimers. Arcemisbéhère L, et al. J Biol Chem, 2010 Feb 26. PMID 20026606, Free PMC Article
    5. Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. Choi JA, et al. Carcinogenesis, 2010 Apr. PMID 19748928

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway.
      Title: LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway.
    2. [Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia].
      Title: [Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia].
    3. Leukotriene B4 receptor 2 correlates with prognosis and immune infiltration in clear cell renal cell carcinoma.
      Title: Leukotriene B4 receptor 2 correlates with prognosis and immune infiltration in clear cell renal cell carcinoma.
    4. Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
      Title: Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
    5. Prognostic and immunological value of LTB4R in pan-cancer.
      Title: Prognostic and immunological value of LTB4R in pan-cancer.
    6. The critical roles of BLT2 on the functions of bronchial epithelial cells.
      Title: Leukotriene B4 receptor 2 regulates the proliferation, migration, and barrier integrity of bronchial epithelial cells.
    7. Authors found that BLT2, a cell surface GPCR for leukotriene B4 and 12hydroxyeicosatetraenoic acid, is highly upregulated in KRAS mutant LOVO and SW480 colorectal cancer cells and plays critical roles in mediating proliferation through activation of phosphatidylinositol 3kinase (PI3K)/protein kinase B (Akt) and subsequent upregulation of cyclin D1.
      Title: Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells.
    8. Our analysis identified six significant (Sidak corrected P < 0.05) depression-associated differentially methylated regions (DMRs); the top-ranked DMR was located in exon 1 of the LTB4R2 gene (Sidak corrected P = 1.27 x 10-14).
      Title: DNA methylation and inflammation marker profiles associated with a history of depression.
    9. In a group of 545 breast cancer patients with metastasis, authors observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup.
      Title: BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer.
    10. BLT2 gene polymorphism (D196G) enhances ligand sensitivity, thereby increasing cell motility in response to low-dose ligand stimulation.
      Title: Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene B4 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in keratinocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    leukotriene B4 receptor 2
    Names
    LTB4 receptor JULF2
    leukotriene B4 receptor BLT2
    seven transmembrane receptor BLTR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164692.3 → NP_001158164.1  leukotriene B4 receptor 2

      See identical proteins and their annotated locations for NP_001158164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK304169, AL096870, BC038437, DC408599
      Consensus CDS
      CCDS9625.2
      UniProtKB/Swiss-Prot
      Q5KU28, Q9NPC1, Q9NPE5
      UniProtKB/TrEMBL
      B4E292
      Related
      ENSP00000445772.1, ENST00000543919.1
      Conserved Domains (2) summary
      cd14964
      Location:23 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21 → 300
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_019839.5 → NP_062813.2  leukotriene B4 receptor 2

      See identical proteins and their annotated locations for NP_062813.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB032558, AK304169, AL096870, DC408599
      Consensus CDS
      CCDS9625.2
      UniProtKB/Swiss-Prot
      Q5KU28, Q9NPC1, Q9NPE5
      UniProtKB/TrEMBL
      B4E292
      Related
      ENSP00000433290.1, ENST00000533293.2
      Conserved Domains (2) summary
      cd14964
      Location:23 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21 → 300
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24310140..24312038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654722.1 Reference GRCh38.p14 PATCHES

      Range
      611118..613016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18508483..18510381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001164693.1: Suppressed sequence

      Description
      NM_001164693.1: This RefSeq was permanently suppressed because there is not sufficient data to support splicing of an intron with non-consensus splice sites in the CDS.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NPC1.2 GenPept UniProtKB/Swiss-Prot:Q9NPC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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