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    PUT4 proline permease PUT4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854530, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PUT4
    Official Full Name
    proline permease PUT4
    Primary source
    SGD:S000005875
    Locus tag
    YOR348C
    See related
    AllianceGenome:SGD:S000005875; FungiDB:YOR348C; VEuPathDB:YOR348C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-proline transmembrane transporter activity. Involved in gamma-aminobutyric acid transport and proline transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PUT4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (986899..988782, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene deoxycytidyl transferase Neighboring gene pyruvate kinase PYK2 Neighboring gene Cin1p Neighboring gene Mne1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. Vandenbol M, et al. Gene, 1989 Nov 15. PMID 2687114
    2. Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast. Poole K, et al. J Gen Appl Microbiol, 2009 Dec. PMID 20118607
    3. Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae. Courchesne WE, et al. Mol Cell Biol, 1983 Apr. PMID 6343842, Free PMC Article
    4. Nitrogen catabolite regulation of proline permease in Saccharomyces cerevisiae. Cloning of the PUT4 gene and study of PUT4 RNA levels in wild-type and mutant strains. Jauniaux JC, et al. Eur J Biochem, 1987 May 4. PMID 3552672
    5. Engineering of yeast Put4 permease and its application to lager yeast for efficient proline assimilation. Omura F, et al. Biosci Biotechnol Biochem, 2005 Jun. PMID 15973048

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables L-proline transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proline transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline permease PUT4
    NP_014993.1
    • Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      986899..988782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183768.1 → NP_014993.1  TPA: proline permease PUT4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W343, P15380
      UniProtKB/TrEMBL
      A6ZPH8, B3LK05, B5VSM4, C7GNS0, G2WNK8, N1NXI3
      Conserved Domains (1) summary
      TIGR00913
      Location:107 → 593
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15380.2

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