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    hrg-7 Aspartic protease 10 [ Caenorhabditis elegans ]

    Gene ID: 182635, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hrg-7
    Official Full Name
    Aspartic protease 10
    Primary source
    WormBase:WBGene00007605
    Locus tag
    CELE_C15C8.3
    See related
    AllianceGenome:WB:WBGene00007605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be located in extracellular region. Predicted to be active in lysosome. Is expressed in amphid neurons; intestine; and phasmid neurons. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See hrg-7 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (12742041..12744171)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PAS domain-containing protein cky-1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Alpha-2-macroglobulin RAP C-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Male-specific behavioral and transcriptomic changes in aging C. elegans neurons. Weng Y, et al. iScience, 2024 Jun 21. PMID 38783998, Free PMC Article
    2. Simple Evaluation of Listeria monocytogenes Pathogenesis Using Caenorhabditis elegans Animal Model. Yang KH, et al. Food Sci Anim Resour, 2019 Feb. PMID 30882077, Free PMC Article
    3. Dysregulated mir-76 mediated a protective response to nanopolystyrene by modulating heme homeostasis related molecular signaling in nematode Caenorhabditis elegans. Liu H, et al. Ecotoxicol Environ Saf, 2021 Apr 1. PMID 33550076
    4. HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Sun F, et al. Nature, 2022 Oct. PMID 36261532, Free PMC Article
    5. Direct and heterologous approaches to identify the LET-756/FGF interactome. Popovici C, et al. BMC Genomics, 2006 May 3. PMID 16672054, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aspartic protease 10
    NP_001256448.1
    • Partially confirmed by transcript evidence
    NP_001256449.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12742041..12744171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269519.3 → NP_001256448.1  Aspartic protease 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E0AHB8, Q18020
      Conserved Domains (1) summary
      cl11403
      Location:71 → 427
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    2. NM_001269520.3 → NP_001256449.1  Aspartic protease 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256449.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0AHB8
      Conserved Domains (1) summary
      pfam00026
      Location:1 → 188
      Asp; Eukaryotic aspartyl protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18020.1

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