U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ST6GAL1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 6480, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ST6GAL1provided by HGNC
    Official Full Name
    ST6 beta-galactoside alpha-2,6-sialyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:10860
    See related
    Ensembl:ENSG00000073849 MIM:109675; AllianceGenome:HGNC:10860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST6N; CDw75; SIAT1; ST6GalI
    Summary
    This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
    Expression
    Broad expression in liver (RPKM 87.7), lymph node (RPKM 37.8) and 18 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ST6GAL1 in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (186930526..187078553)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (189748335..189896308)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186648315..186796341)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186626722-186627417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186627418-186628112 Neighboring gene ribosomal protein S20 pseudogene 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:186647930-186648538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20947 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:186659211-186659712 Neighboring gene ribosomal protein L29 pseudogene 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:186673829-186674071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:186674568-186675068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186681641-186682220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186693287-186694168 Neighboring gene uncharacterized LOC124906314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20949 Neighboring gene Sharpr-MPRA regulatory region 11729 Neighboring gene Sharpr-MPRA regulatory region 4195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20951 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186716158-186717048 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186717049-186717939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20958 Neighboring gene ST6GAL1 promoter P2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20959 Neighboring gene ST6GAL1 promoter P1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20963 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14993 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186789896-186790855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:186854800-186855300 Neighboring gene ribosomal protein L39 pseudogene 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:186856490-186856996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14994 Neighboring gene ribosomal protein L39 like Neighboring gene NANOG hESC enhancer GRCh37_chr3:186888631-186889132 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186892851-186893682 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186893683-186894513 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:186894725-186895400 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:186898085-186898586 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186898587-186899086 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186899087-186899588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186900591-186901090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186901091-186901592 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186903095-186904094 Neighboring gene uncharacterized LOC101929106 Neighboring gene receptor transporter protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Down-regulation of liver Galbeta1, 4GlcNAc alpha2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Gong M, et al. Metabolism, 2008 Dec. PMID 19013288
    2. ST6Gal1 is up-regulated and associated with aberrant IgA1 glycosylation in IgA nephropathy: An integrated analysis of the transcriptome. Liu Y, et al. J Cell Mol Med, 2020 Sep. PMID 32677771, Free PMC Article
    3. Location and mechanism of alpha 2,6-sialyltransferase dimer formation. Role of cysteine residues in enzyme dimerization, localization, activity, and processing. Qian R, et al. J Biol Chem, 2001 Aug 3. PMID 11356854
    4. Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. Wang PH, et al. Gynecol Oncol, 2003 Jun. PMID 12798701
    5. Influences of two significant variants located in the ST6GAL1 3'-untranslated region on lung carcinoma susceptibility in the Chinese Han population. Liu X, et al. Eur J Cancer Prev, 2020 Jan. PMID 31794515

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evaluation of ST6Gal1 expression and clinicopathological significance in human glioma.
      Title: Evaluation of ST6Gal1 expression and clinicopathological significance in human glioma.
    2. N-linked alpha2,6-sialylation of integrin beta1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease.
      Title: N-linked α2,6-sialylation of integrin β1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease.
    3. ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
      Title: ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
    4. CCCTC-binding factor: the specific transcription factor of beta-galactoside alpha-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.
      Title: CCCTC-binding factor: the specific transcription factor of β-galactoside α-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.
    5. Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics.
      Title: Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics.
    6. Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue Analysis and Genomic Datasets.
      Title: Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue Analysis and Genomic Datasets.
    7. Role of the ST6GAL1 sialyltransferase in regulating ovarian cancer cell metabolism.
      Title: Role of the ST6GAL1 sialyltransferase in regulating ovarian cancer cell metabolism.
    8. ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.
      Title: ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.
    9. ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.
      Title: ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.
    10. Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.
      Title: Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.
    Submit: New GeneRIF Correction See all GeneRIFs (97)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
    EBI GWAS Catalog
    Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC48859

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside alpha-2,6-sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
    		  
    involved_in humoral immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mononuclear cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral protein processing TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi medial cisterna IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in Golgi trans cisterna IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-galactoside alpha-2,6-sialyltransferase 1
    Names
    B-cell antigen CD75
    CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
    ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
    ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
    alpha 2,6-ST 1
    sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)
    NP_001340845.1
    NP_003023.1
    NP_775323.1
    NP_775324.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353916.2 → NP_001340845.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform a).
      Source sequence(s)
      AC007488, AC007690
      Consensus CDS
      CCDS3285.1
      UniProtKB/Swiss-Prot
      A8KA14, B2R513, D3DNV3, P15907
      Related
      ENSP00000504448.1, ENST00000676633.1
      Conserved Domains (1) summary
      pfam00777
      Location:169 → 384
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_003032.3 → NP_003023.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform a

      See identical proteins and their annotated locations for NP_003023.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. The promoter and 5' terminal exon sequence is from an endogenous retroviral LTR (PMID: 8724135). Variant 2 is expressed in mature B lymphocytes and variants 1, 2 and 4 encode the same protein (isoform a).
      Source sequence(s)
      AC007488, AC007690
      Consensus CDS
      CCDS3285.1
      UniProtKB/Swiss-Prot
      A8KA14, B2R513, D3DNV3, P15907
      Related
      ENSP00000389337.1, ENST00000448044.5
      Conserved Domains (1) summary
      pfam00777
      Location:169 → 384
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_173216.2 → NP_775323.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform a

      See identical proteins and their annotated locations for NP_775323.1

      Status: REVIEWED

      Source sequence(s)
      AC007488, AC007690, DB152155, X17247
      Consensus CDS
      CCDS3285.1
      UniProtKB/Swiss-Prot
      A8KA14, B2R513, D3DNV3, P15907
      Related
      ENSP00000169298.3, ENST00000169298.8
      Conserved Domains (1) summary
      pfam00777
      Location:169 → 384
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_173217.2 → NP_775324.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform b

      See identical proteins and their annotated locations for NP_775324.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks the exon containing the translation start site compared to variant 1, resulting in an isoform (b) with a shorter N-terminus compared to isoform a. Isoform b is likely to be a soluble rather than membrane-bound protein.
      Source sequence(s)
      AC007488, BC040009, DB152155, DB235666
      Consensus CDS
      CCDS46973.1
      UniProtKB/Swiss-Prot
      P15907
      Related
      ENSP00000412221.2, ENST00000457772.6
      Conserved Domains (1) summary
      pfam00777
      Location:24 → 153
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      186930526..187078553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      189748335..189896308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15907.1 GenPept UniProtKB/Swiss-Prot:P15907

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous